PMID: 9178494May 1, 1997Paper

Complete sequence of two tick-borne flaviviruses isolated from Siberia and the UK: analysis and significance of the 5' and 3'-UTRs

Virus Research
T S GritsunE A Gould

Abstract

The complete nucleotide sequence of two tick-transmitted flaviviruses, Vasilchenko (Vs) from Siberia and louping ill (LI) from the UK, have been determined. The genomes were respectively, 10928 and 10871 nucleotides (nt) in length. The coding strategy and functional protein sequence motifs of tick-borne flaviviruses are presented in both Vs and LI viruses. The phylogenies based on maximum likelihood, maximum parsimony and distance analysis of the polyproteins, identified Vs virus as a member of the tick-borne encephalitis virus subgroup within the tick-borne serocomplex, genus Flavivirus, family Flaviviridae. Comparative alignment of the 3'-untranslated regions revealed deletions of different lengths essentially at the same position downstream of the stop codon for all tick-borne viruses. Two direct 27 nucleotide repeats at the 3'-end were found only for Vs and LI virus. Immediately following the deletions a region of 332-334 nt with relatively conserved primary structure (67-94% identity) was observed at the 3'-non-coding end of the virus genome. Pairwise comparisons of the nucleotide sequence data revealed similar levels of variation between the coding region, and the 5' and 3'-termini of the genome, implying an equivalent st...Continue Reading

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Citations

Mar 12, 2009·Archives of Virology·Kentaro Yoshii, Michael R Holbrook
Jul 26, 2012·Archives of Virology·Nina V KulakovaSergei I Belikov
Mar 5, 2003·Antiviral Research·T S GritsunE A Gould
Mar 12, 2003·Vaccine·Franz X Heinz
Jul 23, 2013·Genome Announcements·Denise A MarstonNicholas Johnson
Jun 20, 2001·Journal of Virology·A A KhromykhE G Westaway
Feb 26, 2005·Journal of Virology·Juliet E BryantAlan D T Barrett
May 31, 2012·Molekuliarnaia biologiia·E L Subbotina, V B Loktev
Feb 24, 2006·Emerging Infectious Diseases·Yoko NukuiIchiro Kurane
Oct 14, 2011·Viruses·Leopoldo G GebhardAndrea V Gamarnik
Jan 23, 2016·Antiviral Research·Natalya L TeterinaAlexander G Pletnev
Oct 14, 2003·Journal of Medical Virology·Mats HaglundAke Lundkvist
Jul 28, 2007·Trends in Parasitology·Kirsty JensenElizabeth J Glass
Jul 4, 2006·Journal of Virological Methods·L MarriottP F Nettleton
May 23, 2001·The Journal of General Virology·D HayasakaI Takashima
Feb 21, 2014·The Journal of General Virology·C L JeffriesN Johnson
Feb 17, 2015·Virus Research·Margo A Brinton, Mausumi Basu
Aug 16, 2008·Virus Research·Sergio M Villordo, Andrea V Gamarnik

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