PMID: 9651245Jul 4, 1998Paper

Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex

Science
S IwataB K Jap

Abstract

Mitochondrial cytochrome bc1 complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. Refined crystal structures of the 11-subunit bc1 complex from bovine heart reveal full views of this bifunctional enzyme. The "Rieske" iron-sulfur protein subunit shows significant conformational changes in different crystal forms, suggesting a new electron transport mechanism of the enzyme. The mitochondrial targeting presequence of the "Rieske" protein (subunit 9) is lodged between the two "core" subunits at the matrix side of the complex. These "core" subunits are related to the matrix processing peptidase, and the structure unveils how mitochondrial targeting presequences are recognized.

References

Oct 21, 1976·Journal of Theoretical Biology·P Mitchell
Apr 20, 1992·Journal of Molecular Biology·E A BerryB K Jap
Nov 1, 1992·Trends in Biochemical Sciences·B S GlickG Schatz
May 31, 1990·European Journal of Biochemistry·H SchäggerG von Jagow
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J P HendrickL E Rosenberg
Jan 1, 1986·Methods in Enzymology·H SchäggerG von Jagow
Jan 1, 1986·Methods in Enzymology·G von Jagow, T A Link
Dec 14, 1972·Biochimica Et Biophysica Acta·M K Wikström, J A Berden
Jan 1, 1994·Critical Reviews in Biochemistry and Molecular Biology·U Brandt, B Trumpower
Feb 15, 1993·The Biochemical Journal·N D Rawlings, A J Barrett
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·V PacesF Kalousek
May 16, 1998·Nature·Z ZhangS H Kim
Nov 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·E A Merritt, M E Murphy
May 1, 1997·Acta Crystallographica. Section D, Biological Crystallography·G N MurshudovE J Dodson
Jan 1, 1989·Photosynthesis Research·A R Crofts, Z Wang

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Citations

Oct 15, 2009·European Biophysics Journal : EBJ·Karen McLuskeyNeil W Isaacs
Apr 25, 2012·Pflügers Archiv : European journal of physiology·Damon Poburko, Nicolas Demaurex
Apr 18, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Edward A Berry, F Ann Walker
Aug 11, 2006·Extremophiles : Life Under Extreme Conditions·Katsuhiko YoshimatsuTaketomo Fujiwara
Dec 31, 2011·Molecules and Cells·Yun Soo BaeYoung Do Yoo
May 21, 2005·Journal of Bioenergetics and Biomembranes·Jeffrey W DoanLawrence I Grossman
Oct 8, 2008·Journal of Bioenergetics and Biomembranes·Natalya V DudkinaHans-Peter Braun
Oct 10, 2008·Journal of Bioenergetics and Biomembranes·Maik HüttemannJeffrey W Doan
Oct 29, 2008·Journal of Bioenergetics and Biomembranes·Sarah E ChobotP Leslie Dutton
May 23, 2013·Photosynthesis Research·Alexander N Tikhonov
Dec 4, 2003·Current Opinion in Chemical Biology·Bohdana M DischerP Leslie Dutton
Apr 9, 2005·Trends in Biochemical Sciences·Artur OsyczkaP Leslie Dutton
Apr 9, 2005·Trends in Biochemical Sciences·Johannes M Herrmann, Kai Hell
Mar 9, 2004·Trends in Plant Science·John F Allen
May 15, 2003·Archives of Biochemistry and Biophysics·Shadi MoghaddasEdward J Lesnefsky
May 6, 2003·Biochemical and Biophysical Research Communications·José C Fernández-Checa
Jun 11, 2002·Journal of Molecular Biology·Heiko BönischRudolf Ladenstein
Apr 11, 2003·Journal of the Neurological Sciences·Michelangelo MancusoSalvatore DiMauro
Mar 16, 2001·Trends in Biotechnology·J K Lanyi, A Pohorille
Oct 15, 2003·Free Radical Biology & Medicine·Satomi MiwaMartin D Brand
Sep 7, 2000·Current Opinion in Biotechnology·A W MunroM D Walkinshaw
Sep 12, 2000·Current Opinion in Structural Biology·T M IversonD C Rees
Sep 2, 2003·Current Opinion in Structural Biology·Mika JormakkaSo Iwata
Jan 23, 1999·Current Opinion in Structural Biology·U ErmlerR K Thauer
Sep 8, 1998·Current Opinion in Structural Biology·M Saraste, J E Walker
Sep 8, 1998·Current Opinion in Structural Biology·A R Crofts, E A Berry
Jul 7, 2001·Trends in Biochemical Sciences·E DarrouzetF Daldal
Mar 5, 2003·Journal of Structural Biology·Anling KuoDeclan A Doyle
Jan 5, 2002·Journal of Molecular Graphics & Modelling·F BasynR Brasseur
Nov 25, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yasuhiro Kashino
Jul 30, 2010·Quarterly Reviews of Biophysics·Kutti R Vinothkumar, Richard Henderson

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