PMID: 9436623Jan 22, 1998Paper

Complete suppresion of ethanol-induced formation of megamitochondria by 4-hydroxy-2,2,6,6-tetramethyl-piperidine-1-oxyl (4-OH-TEMPO)

Free Radical Biology & Medicine
T MatsuhashiT Wakabayashi

Abstract

An attempt has been made to suppress the ethanol-induced formation of megamitochondria (MG) in the rat liver by 4-hydroxy-2,2,6,6-tetramethyl-piperidine-1-oxyl (4-OH-TEMPO), a free radical scavenger, and by allopurinol (AP), a xanthine oxidase inhibitor. Changes observed in the liver of animals given ethanol (EtOH) for 1 month were remarkable decreases both in the body weight gains during the course of the experiment and in the liver weight at the time of sacrifice compared to those of the control; remarkable increases in the level of thiobarbituric acid reactive substances and lipid soluble fluorophores both in microsomes and mitochondria; decreases in the content of cytochrome a+a3 and b and lowered phosphorylating ability of mitochondria; and formation of MG in the liver. A combined treatment of animals with EtOH plus 4-OH-TEMPO completely suppressed the formation of MG in the liver induced by EtOH and distinctly improved the changes caused by EtOH, as specified above, while AP partly suppressed the MG formation. Results described herein provide additional insight into chronic hepatotoxicity of EtOH besides that previously reported. A novelty of the present work is that we were able for the first time to demonstrate reversib...Continue Reading

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Citations

Jan 23, 1999·Free Radical Biology & Medicine·M KarbowskiT Wakabayashi
Mar 4, 2003·Journal of Cellular and Molecular Medicine·T Wakabayashi
Feb 15, 2011·International Journal of Environmental Research and Public Health·Salvador Manzo-Avalos, Alfredo Saavedra-Molina
Aug 23, 2006·The Proceedings of the Nutrition Society·Emanuele Albano
Apr 26, 2003·Virchows Archiv : an International Journal of Pathology·Keiko MashimoYoukichi Ohno
Mar 16, 2000·Experimental and Molecular Pathology·M TeranishiT Wakabayashi
Aug 12, 2021·Therapeutic Advances in Gastroenterology·Paul Middleton, Nikhil Vergis

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