Complex autonomous firing patterns of striatal low-threshold spike interneurons.

Journal of Neurophysiology
Joseph A BeattyCharles J Wilson

Abstract

During sensorimotor learning, tonically active neurons (TANs) in the striatum acquire bursts and pauses in their firing based on the salience of the stimulus. Striatal cholinergic interneurons display tonic intrinsic firing, even in the absence of synaptic input, that resembles TAN activity seen in vivo. However, whether there are other striatal neurons among the group identified as TANs is unknown. We used transgenic mice expressing green fluorescent protein under control of neuronal nitric oxide synthase or neuropeptide-Y promoters to aid in identifying low-threshold spike (LTS) interneurons in brain slices. We found that these neurons exhibit autonomous firing consisting of spontaneous transitions between regular, irregular, and burst firing, similar to cholinergic interneurons. As in cholinergic interneurons, these firing patterns arise from interactions between multiple intrinsic oscillatory mechanisms, but the mechanisms responsible differ. Both neurons maintain tonic firing because of persistent sodium currents, but the mechanisms of the subthreshold oscillations responsible for irregular firing are different. In LTS interneurons they rely on depolarization-activated noninactivating calcium currents, whereas those in cho...Continue Reading

References

Mar 1, 1992·Trends in Neurosciences·S R Vincent, B T Hope
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T M DawsonS H Snyder
Jan 1, 1988·Annual Review of Pharmacology and Toxicology·T BartfaiP Serfözö
Aug 1, 1972·Electroencephalography and Clinical Neurophysiology·P Feltz, D Albe-Fessard
Jun 20, 1982·The Journal of Comparative Neurology·H T ChangS T Kitai
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M KimuraE Evarts
Mar 1, 1995·Journal of Neurophysiology·T AosakiA M Graybiel
Jan 23, 1995·The Journal of Comparative Neurology·W RushlowC C Naus
Jan 1, 1993·Progress in Brain Research·H Kita
Dec 1, 1995·Trends in Neurosciences·Y KawaguchiP C Emson
Oct 3, 1998·The European Journal of Neuroscience·P CalabresiG Bernardi
May 13, 1999·Nature Neuroscience·T Koós, J M Tepper
May 11, 2000·Journal of Neurophysiology·C J Wilson, J C Callaway
Feb 13, 2001·Journal of Neuroscience Methods·I Bar-GadH Bergman
Feb 2, 2002·Neuroscience·C VilchisE Galarraga
Jul 9, 2002·The European Journal of Neuroscience·Diego CentonzePaolo Calabresi
Aug 1, 1960·Electroencephalography and Clinical Neurophysiology·D ALBE-FESSARDE OSWALDO-CRUZ
Sep 30, 2003·Reviews in the Neurosciences·Diego CentonzePaolo Calabresi
Nov 5, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·C Savio ChanD James Surmeier
Apr 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas MalletFrançois Gonon
Aug 12, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Weixing ShenD James Surmeier
Sep 16, 2005·Journal of Neurophysiology·Charles J Wilson, Joshua A Goldberg
Nov 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joshua A Goldberg, Charles J Wilson
Mar 24, 2006·Journal of Neurophysiology·Rodolfo R Llinás, Mircea Steriade
Feb 14, 2008·Neurochemical Research·Violeta Gisselle Lopez-HuertaElvira Galarraga
Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew SharottAndreas K Engel
Jun 19, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nathalie DehorterConstance Hammond
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joshua A GoldbergCharles J Wilson
Sep 18, 2009·Journal of Neurophysiology·John G PartridgeStefano Vicini
Feb 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aryn H GittisAnatol C Kreitzer

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Citations

Sep 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason Yamada-Hanff, Bruce P Bean
Dec 5, 2015·Frontiers in Cellular Neuroscience·Craig P BlomeleyEnrico Bracci
Sep 10, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Marta MalteseAntonio Pisani
Apr 17, 2015·Annals of the New York Academy of Sciences·Kalynda K Gonzales, Yoland Smith
Jun 9, 2015·Current Opinion in Neurobiology·Gilad Silberberg, J Paul Bolam
Apr 30, 2015·Stem Cell Reports·Wenze NiuChun-Li Zhang
Feb 24, 2015·Progress in Neurobiology·K L Eskow JaunarajsA Pisani
Sep 23, 2014·Neuropharmacology·Marianela Garcia-MunozGordon W Arbuthnott
May 21, 2016·Frontiers in Cellular Neuroscience·Rasha ElghabaEnrico Bracci
Feb 27, 2018·The European Journal of Neuroscience·Maxime Assous, James M Tepper
Dec 21, 2017·Frontiers in Cellular Neuroscience·Rasha Elghaba, Enrico Bracci
May 26, 2018·The European Journal of Neuroscience·Nilupaer AbudukeyoumuGordon W Arbuthnott
Nov 21, 2014·Journal of Neurophysiology·Joseph A BeattyCharles J Wilson
Jul 25, 2019·The European Journal of Neuroscience·Alexandria E Melendez-ZaidiDalton James Surmeier
Nov 1, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Joshua L Plotkin, Joshua A Goldberg
Apr 18, 2020·The European Journal of Neuroscience·Cecilia Tubert, Mario Gustavo Murer
Nov 24, 2018·Frontiers in Neuroanatomy·James M TepperMaxime Assous
Jul 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kianoush Banaie BoroujeniThilo Womelsdorf
Jul 14, 2020·Frontiers in Neural Circuits·Juan C MoralesCharles J Wilson
Nov 8, 2014·Journal of Neurophysiology·Lie WangWilliam E Armstrong
Apr 9, 2021·Cell Calcium·Wojciech Ambroziak, Jan Siemens
Jul 25, 2021·Current Biology : CB·Elizabeth N HollyMarc V Fuccillo

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