PMID: 2108127Apr 1, 1990Paper

Complex character of senS, a novel gene regulating expression of extracellular-protein genes of Bacillus subtilis

Journal of Bacteriology
L F Wang, R H Doi

Abstract

The senS gene of Bacillus subtilis, which in high copy number stimulates the expression of several extracellular-protein genes, has been cloned, genetically mapped, and sequenced. The gene codes for a highly charged basic protein containing 65 amino acid residues. The gene is characterized by the presence of a transcription terminator (attenuator) located between the promoter and open reading frame, a strong ribosome-binding site, and a strong transcription terminator at the 3' end of this monocistronic gene. The amino acid sequence of SenS showed partial homology with the N-terminal core binding domain region of bacterial RNA polymerase sigma factors and a helix-turn-helix motif found in DNA-binding proteins. The gene can be deleted without any effect on growth or sporulation.

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Citations

Jan 1, 1994·Molecular & General Genetics : MGG·V N MironovK G Skryabin
Dec 3, 2005·Journal of Bacteriology·Eiji KawachiTeruo Tanaka
Jun 1, 1997·Microbiology·N J Cummings, I F Connerton

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