Complex clonal features in an mycobacterium tuberculosis infection in a two-year-old child

The Pediatric Infectious Disease Journal
Darío García de ViedmaEmilio Bouza

Abstract

The focus of this report is to describe the highly complex clonal features of the Mycobacterium tuberculosis (MTB) isolates cultured from a 2-year-old child with no risk factors for tuberculosis. Molecular analysis showed that she was coinfected by 2 MTB isolates. The coinfecting isolates showed only subtle genetic differences and shared equivalent infectivity in vitro; however, they were infecting independent anatomic sites (compartmentalized infection). One of the MTB isolates was cultured only from respiratory specimens, whereas the other was isolated from extrarespiratory site (central nervous system).

References

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Jan 1, 2004·American Journal of Respiratory and Critical Care Medicine·Robin M WarrenPaul D van Helden
Aug 7, 2004·Journal of Clinical Microbiology·Darío García de ViedmaEmilio Bouza
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Nov 17, 2005·The Journal of Infectious Diseases·Dario Garcia de ViedmaEmilio Bouza

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Citations

Oct 30, 2008·The Journal of Infectious Diseases·Nicholas A BeSanjay K Jain
Aug 6, 2010·Journal of Clinical Microbiology·Sahal A M Al-HajojAdri G M van der Zanden
Sep 24, 2011·Journal of Clinical Microbiology·Laura Pérez-LagoDarío García de Viedma
Aug 1, 2007·BMC Microbiology·Ana MartínDarío García de Viedma
Feb 7, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L Pérez-LagoD García-de-Viedma
Feb 22, 2012·Tuberculosis·Laura Pérez-LagoDarío García de Viedma
Mar 19, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Laura Pérez-LagoDarío García-de-Viedma
Jan 5, 2014·BioMed Research International·Sanjay K JainRenu Bharadwaj
Mar 30, 2017·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Hawra Al-Ghafli, Sahal Al-Hajoj
Nov 14, 2016·Microbiology Spectrum·Stefan NiemannPhilip Supply

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