Complex cytokine profiles induced by BCG vaccination in UK infants.

Vaccine
Maeve K LalorHazel M Dockrell

Abstract

IFNgamma plays an important part in immunity to tuberculosis (TB), but although it is necessary, it is not on its own sufficient for protection against TB. To identify other cytokines that play a role in the protection against TB induced by BCG vaccination, immune responses were compared between vaccinated and unvaccinated infants from the UK where BCG is known to provide protection. Twenty-one cytokines and chemokines were tested in supernatants from diluted whole blood cultures that had been stimulated for 6 days with Mycobacterium tuberculosis PPD. For 15 out of 21 of the cytokines tested responses were much higher in BCG vaccinated infants than in unvaccinated infants. These included: pro-inflammatory cytokines; IFNgamma (median 1705 pg/ml vs. 1.6 pg/ml in vaccinated and unvaccinated infants, respectively), TNFalpha (median 226 pg/ml vs. 18 pg/ml), as well as IL-2, IL-1alpha and IL-6; TH2 cytokines: IL-4, IL-5 and IL-13 (median 104 pg/ml vs. 1.6 pg/ml); the regulatory cytokine IL-10 (median response 96 pg/ml vs. 8 pg/ml); the TH17 cytokine IL-17, chemokines (IP-10, MIP-1alpha and IL-8) and growth factors (GM-CSF and G-CSF). The greatest increase in cytokine production in BCG vaccinees compared to unvaccinated infants was se...Continue Reading

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Citations

Sep 23, 2014·BMC Research Notes·Amy S M KennellMyer R Salaman
Sep 2, 2011·The Journal of Infectious Diseases·Maeve K LalorHazel M Dockrell
Jul 17, 2012·Pediatric Research·Nadège GourgouillonGhislaine Sterkers
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Aug 21, 2013·The Journal of Infection·Marine ArmandGhislaine Sterkers
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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
ELISA
ELISAs
FACS

Software Mentioned

Bioplex manager
Multiplex

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