Complex ecological dynamics and eradicability of the vector borne macroparasitic disease, lymphatic filariasis.

PloS One
Manoj Gambhir, E Michael

Abstract

The current global efforts to control the morbidity and mortality caused by infectious diseases affecting developing countries--such as HIV/AIDS, polio, tuberculosis, malaria and the Neglected Tropical Diseases (NTDs)-have led to an increasing focus on the biological controllability or eradicability of disease transmission by management action. Here, we use an age-structured dynamical model of lymphatic filariasis transmission to show how a quantitative understanding of the dynamic processes underlying infection persistence and extinction is key to evaluating the eradicability of this macroparasitic disease. We investigated the persistence and extinction dynamics of lymphatic filariasis by undertaking a numerical equilibrium analysis of a deterministic model of parasite transmission, based on varying values of the initial L3 larval density in the system. The results highlighted the likely occurrence of complex dynamics in parasite transmission with three major outcomes for the eradicability of filariasis. First, both vector biting and worm breakpoint thresholds are shown to be complex dynamic entities with values dependent on the nature and magnitude of vector-and host specific density-dependent processes and the degree of host...Continue Reading

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Citations

Nov 13, 2010·PLoS Neglected Tropical Diseases·Michelle L MichalskiBruce M Christensen
Apr 2, 2013·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Yogesh Kumar YadavOneal Gupta
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Feb 9, 2017·Infectious Diseases of Poverty·Edwin Michael, Shirin Madon
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Dec 20, 2019·The Journal of Infectious Diseases·Joaquin M PradaT Déirdre Hollingsworth
May 1, 2012·PLoS Neglected Tropical Diseases·María-Gloria BasáñezThomas S Churcher
Jul 21, 2011·Asian Pacific Journal of Tropical Medicine·Kiran Yagain, Mary Mathew
Mar 11, 2017·Computational and Mathematical Methods in Medicine·Yan ChengMingfeng He
Nov 2, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Paul S WeissFrank O Richards
Jan 26, 2021·Royal Society Open Science·Shakir BilalEdwin Michael

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