PMID: 16613094Apr 15, 2006Paper

Complex evaluation of the action of inhibitors of hydrochloric acid secretion on gastric function in ulcer disease

Terapevticheskiĭ arkhiv
Ia M Vakhrushev, O V Muravtseva

Abstract

To characterize actions of inhibitors of hydrochloric acid secretion on gastric function and to formulate indications to using different antisecretory drugs in ulcer disease (UD). Of 120 examinees with duodenal ulcer (DU), 40 received gastrocepin, 40--famotidin, 40--omeprasol. Follow-up study was made of motor, acid-, pepsin- and mucus-forming functions of the stomach. By reducing production of acid and pepsin, gastrocepin is inferior to famotidin and omeprasol. Gastrocepin is more effective than famotidin and omeprasol in motor-evacuatory dysfunction. Gastrocepin improves defensive properties of gastric mucus better. The results expand indications for a differential administration of antisecretory drugs in UD.

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