Complex expression changes of the placental endothelin system in early and late onset preeclampsia, fetal growth restriction and gestational diabetes

Life Sciences
Martina Dieber-RothenederMila Cervar-Zivkovic

Abstract

Preeclampsia (PE), fetal growth restriction (FGR) and gestational diabetes mellitus (GDM) are major pregnancy complications affecting maternal and fetal health. The placenta and the vasoconstrictor endothelin-1 (ET-1) have a controlling and mediating role in these conditions. This study tested the hypothesis that the expression of ET-1 and its receptors (ET(A) and ET(B)) is altered in these pathologies and differs between early (gestational week [GW] ≤ 34) and late (GW > 34) third trimester pregnancies. The study included 88 women (GW 28-41) with PE (blood pressure >140/90 mmHg, protein >300 mg/24 hrs; n=14), FGR (<10th birthweight centile and pathological umbilical blood flow; n=13), PE+FGR (n=5) and GDM (n=21), and gestational age-matched controls (n=35). ET-1, ET(A) and ET(B) mRNA and ET(A) and ET(B) protein were quantified in placental tissues by real-time PCR and immunoblotting. The ET/ETR mRNA system is altered in PE and PE+FGR and GDM. Expression of ET-1, ET(A) and ET(B) is upregulated in early onset PE and PE+FGR with stronger effect in PE+FGR. GDM down regulated ET/ETR mRNA in the placentas in late third trimester of pregnancy. ET/ETR protein is virtually unchanged. Early onset PE (≤GW34) with or without FGR is associa...Continue Reading

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Citations

Aug 19, 2015·Free Radical Biology & Medicine·Sarah J ChappleGiovanni E Mann
Apr 6, 2019·Current Pharmaceutical Design·Emilie HitzerdA H Jan Danser
Nov 16, 2019·Journal of the American Heart Association·Martina A SteurerLaura L Jelliffe-Pawlowski
Nov 7, 2017·Journal of Diabetes Research·Roberto Villalobos-LabraLuis Sobrevia
Jul 22, 2021·International Journal of General Medicine·Ebtisam Al-OfiNora Hakami
Aug 17, 2021·Frontiers in Physiology·Mazhar PashaChristy-Lynn M Cooke

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