Complex formation between calsequestrin and the ryanodine receptor in fast- and slow-twitch rabbit skeletal muscle

FEBS Letters
B E Murray, K Ohlendieck

Abstract

Linkage between the high-capacity Ca2+-binding protein calsequestrin and the ryanodine receptor is proposed to be essential for proper Ca2+-release during skeletal muscle excitation-contraction coupling. However, no direct biochemical evidence exists showing a connection between these high-molecular-mass complexes in native skeletal muscle membranes. Here, using immunoblot analysis of chemically crosslinked membrane vesicles enriched in triad junctions, we have demonstrated that a very close neighborhood relationship exists between calsequestrin and the ryanodine receptor in both main fiber types. Hence, the luminal Ca2+-reservoir complex appears to be directly coupled to the membrane Ca2+-release complex and oligomerization seems to be of functional importance.

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Citations

Aug 30, 2008·European Biophysics Journal : EBJ·Bjørn Gilbert Nielsen
Aug 8, 2008·Bulletin of Experimental Biology and Medicine·O M VekshinaN L Vekshin
Jul 5, 2003·Analytical Biochemistry·Claire Mulvey, Kay Ohlendieck
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Sep 17, 2002·European Journal of Biochemistry·Louise GloverKay Ohlendieck
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Aug 12, 2009·Aging Cell·Jackson R TaylorOsvaldo Delbono
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Jun 19, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rosana FerrariMaria Alice da Cruz Höfling
Dec 2, 2011·Journal of Muscle Research and Cell Motility·Feliciano ProtasiMarco Quarta
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Aug 12, 1999·Biochemical and Biophysical Research Communications·G R FroemmingK Ohlendieck
Apr 21, 1999·Biochimica Et Biophysica Acta·G R FroemmingK Ohlendieck

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