Complex formation equilibria of polyamine ligands with copper(II) and zinc(II)

Journal of Inorganic Biochemistry
Valeria M NurchiAlicia Domínguez Martín

Abstract

A comprehensive study of the protonation equilibria of a series of polyamine ligands along with their complex formation equilibria with Cu2+ and Zn2+ is reported in this work. The primary aim of this study has been the achievement of homogeneous thermodynamic data on these ligands, in order to evaluate their influence on the homeostatic equilibria of essential metal ions (Cu2+ and Zn2+) in biological fluids. These polyamines are largely used as linkers in the building of chelating agents for iron overload. Potentiometric and spectrophotometric techniques were used for the characterization of protonation and complex formation constants. In addition, the characterization of the formed complexes is discussed together with selected solid-state crystal structures, remarking the influence of the length of the chain and of the linear or tetradentate tripod nature of the polyamine ligands on the stability of the complexes.

References

Aug 25, 1971·Journal of the American Chemical Society·H HauerD W Margerum
May 10, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Valeria M NurchiTadeusz Lis
Dec 4, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Valeria M NurchiGarth J S Cooper
Jul 2, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Valeria Marina NurchiMaria Antonietta Zoroddu
Apr 25, 2018·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Joanna I LachowiczValeria M Nurchi

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