PMID: 9445058Jan 28, 1998Paper

Complex formation facilitates endocytosis of the varicella-zoster virus gE:gI Fc receptor

Journal of Virology
J K Olson, C Grose

Abstract

Open reading frames within the unique short segment of alphaherpesvirus genomes participate in egress and cell-to-cell spread. The case of varicella-zoster virus (VZV) is of particular interest not only because the virus is highly cell associated but also because its most prominent cell surface protein, gE, bears semblance to the mammalian Fc receptor Fc gammaRII. A previous study demonstrated that when expressed alone in cells, VZV gE was endocytosed from the cell surface through a tyrosine localization motif in its cytoplasmic tail (J. K. Olson and C. Grose, J. Virol. 71:4042-4054, 1997). Since VZV gE is normally found in association with gI in the infected cell, the present study was directed at defining the trafficking of the VZV gE:gI protein complex. First, VZV gI underwent endocytosis and recycling when it was expressed alone in cells, and interestingly, VZV gI contained a methionine-leucine internalization motif in its cytoplasmic tail. Second, VZV gI was found by confocal microscopy to colocalize with VZV gE during endocytosis and recycling in cells. Third, by a quantitative internalization assay, VZV gE:gI was shown to undergo endocytosis more efficiently (steady state, 55 to 60%) than either gE alone (steady state, a...Continue Reading

References

Aug 1, 1991·Current Opinion in Cell Biology·I S Trowbridge
Nov 1, 1990·Nature·B MossT R Fuerst
Jan 1, 1989·Annual Review of Cell Biology·J Gruenberg, K E Howell
Feb 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·E A MontalvoC Grose
Sep 1, 1986·The Journal of General Virology·A J Davison, J E Scott
Nov 1, 1995·Journal of Virology·K S DingwellD C Johnson
Mar 31, 1995·Journal of Molecular Biology·D J McGeochE A Telford
Jan 1, 1993·Annual Review of Cell Biology·I S TrowbridgeC R Hopkins
Jan 1, 1996·The Journal of Cell Biology·W StoorvogelH J Geuze
Feb 1, 1997·BioTechniques·C HatfieldC Grose
Aug 1, 1994·Trends in Cell Biology·I V Sandoval, O Bakke

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Citations

Aug 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Leigh ZerboniAnn M Arvin
Feb 8, 2008·Journal of Virology·Mike ReicheltAnn M Arvin
Jan 22, 2004·The Journal of Biological Chemistry·Elizabeth R SpraguePamela J Bjorkman
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Barbara BerarducciAnn M Arvin
May 30, 1998·Journal of Virology·R S Tirabassi, L W Enquist
Aug 8, 1998·Journal of Virology·J D MijnesR J de Groot
Mar 12, 1999·Journal of Virology·R S Tirabassi, L W Enquist
Aug 15, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·A D BrideauR S Tirabassi
Oct 22, 2002·Journal of Virology·Yasuyuki GomiKoichi Yamanishi
May 21, 2011·Virology Journal·Lijuan LiXiaoyue Chen

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