PMID: 2508079Jul 1, 1989Paper

Complex formation of p-boronophenylalanine with some monosaccharides

Pigment Cell Research
Y MoriH Kakihana

Abstract

To increase the solubility of p-boronophenylalanine (p-bpa) in neutral pH solution, the complex formation of p-bpa with some monosaccharides has been studied by 11B-NMR and UV spectroscopy. The complex formation constants (log K) obtained by the UV method in pH 7.4 solution are 2.43 (fructose), 2.19 (mannitol), 1.28 (galactose), 1.10 (mannose), and 0.85 (glucose), respectively. One hundred milligrams of p-bpa is able to dissolve in 3 ml of 0.3 M fructose solution at pH 7.98. Based on the results obtained, the behavior of p-bpa-monosaccharide complexes in vivo after injection of the complex solution is described.

Citations

Apr 5, 2003·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·T M Bulbul IslamAkinobu Sasane
Apr 26, 2011·Journal of Radiation Research·Sami HeikkinenPetri Melkko
Apr 27, 2013·Future Medicinal Chemistry·Srinivasa R MarepallyGeorge W Kabalka
Jul 4, 1998·Journal of Microencapsulation·P Perugini, F Pavanetto
Aug 1, 2020·Frontiers in Chemistry·Paul HoppenzAnnette G Beck-Sickinger
Jan 6, 2021·Chemical Communications : Chem Comm·Manisha LambaAnupam Bandyopadhyay
Feb 27, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Takahiro NomotoNobuhiro Nishiyama
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin KellertEvamarie Hey-Hawkins
Sep 14, 2013·Journal of the American Chemical Society·Stephanie DeshayesKazunori Kataoka
Mar 20, 2003·Journal of the American Chemical Society·Hidenori OtsukaKazunori Kataoka
Feb 19, 2002·Chemical Reviews·Albert H. SolowayJ. Gerald Wilson

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