Complex genetic structures with repeated elements, a sul-type class 1 integron, and the blaVEB extended-spectrum beta-lactamase gene.

Antimicrobial Agents and Chemotherapy
T NaasPatrice Nordmann

Abstract

Two clinical isolates of Pseudomonas aeruginosa, TL-1 and TL-2, were isolated from a patient transferred from Bangladesh and hospitalized for osteomyelitis in Paris, France. P. aeruginosa TL-1 expressed the extended-spectrum beta-lactamase VEB-1a and was susceptible only to imipenem and colistin, while P. aeruginosa TL-2 expressed only the naturally occurring bla(AmpC) gene at a basal level and exhibited a wild-type beta-lactam resistance phenotype. In TL-1, the typical 5'-end conserved sequence (5'-CS) region of class 1 integrons usually present upstream of the bla(VEB-1a) gene was replaced by a truncated 3'-CS and a 135-bp repeated element (Re). Downstream of the bla(VEB-1a) gene, an insertion sequence, ISPa31 disrupted by ISPa30, and an orf513 sequence, belonging to a common region (conserved region 1 [CR1]) immediately upstream of the aphA-6 gene, were present. Further downstream, a second truncated 3'-CS region in direct repeat belonged to In51, an integron containing two gene cassettes (aadA6 and the OrfD cassette). Thus, the overall structure corresponded to a sul-type class 1 integron termed In121. Genetic analyses revealed that both isolates were clonally related and differed by a ca. 100-kb fragment that contained In1...Continue Reading

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Citations

Jul 30, 2008·Antimicrobial Agents and Chemotherapy·Thierry NaasPatrice Nordmann
Aug 26, 2009·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Dec 15, 2010·Antimicrobial Agents and Chemotherapy·Delphine GirlichPatrice Nordmann
Jan 14, 2009·Antimicrobial Agents and Chemotherapy·Zhiyong ZongJonathan R Iredell
Jan 30, 2008·Antimicrobial Agents and Chemotherapy·Thierry NaasPatrice Nordmann
Apr 25, 2013·Antimicrobial Agents and Chemotherapy·Frédéric JanvierAudrey Mérens
Apr 4, 2013·Theoretical Biology & Medical Modelling·Abdelmonaem MessaoudiJeannette Ben Hamida
May 14, 2011·FEMS Microbiology Reviews·Sally R Partridge
Jan 10, 2009·Acta Microbiologica Et Immunologica Hungarica·Zorica LepsanovicM Füzi
Mar 15, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Laurent PoirelPatrice Nordmann
Dec 25, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L PoirelP Nordmann
Dec 25, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T NaasP Nordmann
Aug 10, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Khadidja YousfiSadjia Bekal
Sep 21, 2016·Antimicrobial Agents and Chemotherapy·Ruichao LiSheng Chen
Sep 4, 2014·Antimicrobial Agents and Chemotherapy·Anand Prakash MauryaAmitabha Bhattacharjee
Feb 22, 2008·Journal of Medical Microbiology·Hélène Réglier-PoupetPatrice Nordmann
Apr 21, 2021·Klinicheskaia laboratornaia diagnostika·M V Kuznetsova, J S Gizatullina

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