Complex HLA association in paraneoplastic cerebellar ataxia with anti-Yo antibodies

Journal of Neuroimmunology
Ryan P HillaryEmmanuel Mignot

Abstract

Anti-Yo paraneoplastic cerebellar degeneration (PCD) is a devastating autoimmune complication of gynecological cancers. We hypothesized that as for other autoimmune diseases, specific HLA haplotypes are associated. We conducted high resolution HLA typing of Class I/Class II in 40 cases versus ethnically matched controls. Three cases with anti-Yo antibodies and peripheral neuropathy were also included. We detected protective effects of DPA1*01:03~DPB1*04:01 (OR=0, p=0.0008), DRB1*04:01~DQA1*03:03(OR=0, p=0.0016) and DPA1*01:03~DPB1*04:01 (OR=0.35, p=0.0047) overall. Increased DRB1*13:01~DQA1*01:03~DQB1*06:03 was also found in PCD ovarian cases (OR=5.4, p=0.0016). These results suggest differential genetic susceptibility to anti-Yo per cancer and with a primary HLA Class II involvement.

Citations

Jul 14, 2020·Frontiers in Immunology·Lidia YshiiRoland Liblau
Mar 15, 2019·Nature Reviews. Clinical Oncology·Francesc Graus, Josep Dalmau
Mar 5, 2020·Auto- Immunity Highlights·Sergio Muñiz-CastrilloJérôme Honnorat
Jul 9, 2020·Therapeutic Advances in Neurological Disorders·Alberto VogrigJérôme Honnorat
Jun 15, 2018·British Journal of Cancer·Clément Vialatte de PémilleAgusti Alentorn
Jul 15, 2021·Gynecologic Oncology Reports·Michalis LiontosMeletios-Athanasios Dimopoulos

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