Complex interactions with infection and diet may explain seasonal growth responses to vitamin A in preschool aged Indonesian children

European Journal of Clinical Nutrition
H HadiK P West

Abstract

To explore the potential contribution of respiratory infections and vitamin A intakes to the seasonal effect of vitamin A supplementation on child growth. Data from a randomized double-blind placebo-controlled trial, in which a single high dose of vitamin A or placebo was given every 4 months to 1405 children aged 6-48 months were used for the analysis. In total, 4430 child-treatment cycles were examined, and for each cycle the children had their dietary intake, weight, and height assessed at the start and end. Linear regression models of the difference in height and weight during each treatment cycle were used and the within-child correlation was adjusted using the generalized estimating equations (GEE). Other covariables in the model included age, sex, percentage of days with acute lower respiratory infection and diarrhea, and cumulative doses of vitamin A. This study showed that a significant effect of vitamin A supplementation on linear growth was observed in all seasons in children with a low burden of respiratory infections, that is, < 21.5% of days with respiratory illness. In each season, the highest effect was found in children with a low burden of respiratory infections and low vitamin A intakes, that is, intakes < 40...Continue Reading

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Citations

Feb 1, 2014·American Journal of Physical Anthropology·Emma PomeroyJay T Stock
Mar 11, 2017·The Cochrane Database of Systematic Reviews·Aamer ImdadZulfiqar A Bhutta
Oct 5, 2011·Maternal & Child Nutrition·Kathryn G Dewey, Daniel R Mayers

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