PMID: 2487152Nov 1, 1989Paper

Complex karyotypic anomalies in a bizarre leiomyoma of the uterus

Genes, Chromosomes & Cancer
M NilbertF Mitelman

Abstract

Cytogenetic investigation of short-term cultures from a bizarre leiomyoma of the uterus, a tumor type not hitherto karyotypically characterized, revealed two abnormal clones with multiple complex rearrangements. Three-fourths of the aberrant cells were hypodiploid with the composite karyotype 38-44,XX,-6,-7,-10, -11,+20,-22,r(1),der(2)(:2p23----cen----2q13::1q21---- 1qter),der(2)t(2; 9)(p21;q13),t(5;?)(q35;?), t(5;?),(q35;?),+der(5)t(5;15)(q11;q15), der(8)t(8;11)(q24;q13),t(15;?)(p12;?),der(16)t(12;16)(q13;p13),+r,+mar. The remaining abnormal mitoses were hypotetraploid, with chromosome numbers ranging from 74 to 86. These massively rearranged cells showed the same markers that were found in the hypodiploid clone, but in duplicate, indicating that this clone had arisen through polyploidization of hypodiploid cells. Flow cytometry revealed a DNA index of 1.03.

References

Sep 1, 1989·Genes, Chromosomes & Cancer·N MandahlF Mitelman
Nov 1, 1987·Archives of Surgery·C P KarakousisA A Sandberg
Jan 1, 1988·Cancer Genetics and Cytogenetics·N MandahlF Mitelman
Jan 1, 1989·Cancer Genetics and Cytogenetics·R VanniU Lecca
Jan 1, 1985·Human Genetics·N MandahlH Willén
Jun 1, 1988·Cancer Genetics and Cytogenetics·P Dal CinA A Sandberg
Sep 1, 1988·Cancer Genetics and Cytogenetics·L BoghosianA A Sandberg
Jan 1, 1988·Cytogenetics and Cell Genetics·M NilbertF Mitelman
May 1, 1988·Cancer Genetics and Cytogenetics·Z GibasB S Emanuel
May 1, 1988·Cancer Genetics and Cytogenetics·C Turc-CarelA A Sandberg
Feb 1, 1987·Cancer Genetics and Cytogenetics·S HeimH Willén
Jun 15, 1987·International Journal of Cancer. Journal International Du Cancer·N MandahlF Mitelman
Nov 1, 1980·Cytometry·J T ThornthwaiteW J Temple

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Citations

Apr 1, 1993·Genes, Chromosomes & Cancer·P Dal CinH Van Den Berghe
Oct 1, 1990·Cancer Genetics and Cytogenetics·N PandisS Fotiou
Aug 1, 1991·Cancer Genetics and Cytogenetics·N PandisF Mitelman
Dec 1, 1994·Cancer Genetics and Cytogenetics·L R Donner
Feb 12, 1999·Cancer Genetics and Cytogenetics·P PolitoH Van den Berghe
Dec 1, 2009·Surgical Pathology Clinics·Paola Dal Cin
May 1, 1990·Genes, Chromosomes & Cancer·M Nibert, S Heim
Nov 1, 1990·Genes, Chromosomes & Cancer·N PandisF Mitelman

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