Complex regulatory network encompassing the Csr, c-di-GMP and motility systems of Salmonella Typhimurium.

Environmental Microbiology
Kristina JonasOjar Melefors

Abstract

Bacterial survival depends on the ability to switch between sessile and motile lifestyles in response to changing environmental conditions. In many species, this switch is governed by (3'-5')-cyclic-diguanosine monophosphate (c-di-GMP), a signalling molecule, which is metabolized by proteins containing GGDEF and/or EAL domains. Salmonella Typhimurium contains 20 such proteins. Here, we show that the RNA-binding protein CsrA regulates the expression of eight genes encoding GGDEF, GGDEF-EAL and EAL domain proteins. CsrA bound directly to the mRNA leaders of five of these genes, suggesting that it may regulate these genes post-transcriptionally. The c-di-GMP-specific phosphodiesterase STM3611, which reciprocally controls flagella function and production of biofilm matrix components, was regulated by CsrA binding to the mRNA, but was also indirectly regulated by CsrA through the FlhDC/FliA flagella cascade and STM1344. STM1344 is an unconventional (c-di-GMP-inactive) EAL domain protein, recently identified as a negative regulator of flagella gene expression. Here, we demonstrate that CsrA directly downregulates expression of STM1344, which in turn regulates STM3611 through fliA and thus reciprocally controls motility and biofilm fa...Continue Reading

References

Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·K A Datsenko, B L Wanner
Nov 18, 2000·Infection and Immunity·A M Prouty, J S Gunn
Nov 18, 2000·Infection and Immunity·C AltierS D Lawhon
Sep 15, 2001·FEMS Microbiology Letters·M Y GalperinE V Koonin
Jun 18, 2002·Molecular Microbiology·Carol S BakerPaul Babitzke
Aug 24, 2002·Journal of Bacteriology·Kazushi SuzukiTony Romeo
Apr 16, 2003·Molecular Microbiology·Thomas WeilbacherTony Romeo
Jun 7, 2003·Molecular Microbiology·Sara D LawhonCraig Altier
Dec 4, 2003·Journal of Bacteriology·Max TeplitskiBrian M M Ahmer
Mar 20, 2004·The Journal of Biological Chemistry·Claudio ValverdeDieter Haas
May 15, 2004·Environmental Microbiology·Michael Y Galperin
Oct 2, 2004·Molecular Microbiology·Begoña GarcíaIñigo Lasa
Apr 9, 2005·Cellular and Molecular Life Sciences : CMLS·U Römling
Mar 4, 2006·Journal of Bacteriology·Jonathan FryeKelly T Hughes
Mar 15, 2006·Current Opinion in Microbiology·Ute Römling, Dorit Amikam
Apr 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert P RyanJ Maxwell Dow
Sep 19, 2006·Journal of Bacteriology·Verónica MondragónDimitris Georgellis
Oct 27, 2006·FEMS Microbiology Letters·Kristina JonasOjar Melefors
Jan 9, 2007·Current Opinion in Microbiology·Peggy A Cotter, Scott Stibitz
Mar 27, 2007·Current Opinion in Microbiology·Paul Babitzke, Tony Romeo
May 8, 2007·Annual Review of Microbiology·Rita TamayoAndrew Camilli

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Citations

May 24, 2013·Genes & Development·Erik Holmqvist, Jörg Vogel
Mar 6, 2012·Journal of Bacteriology·Olga E Petrova, Karin Sauer
Mar 9, 2013·Microbiology and Molecular Biology Reviews : MMBR·Ute RömlingMark Gomelsky
Nov 13, 2013·International Journal of Molecular Sciences·Ethel Seyll, Laurence Van Melderen
Dec 2, 2014·Future Microbiology·Roger SimmUte Römling
May 7, 2010·Cellular and Molecular Life Sciences : CMLS·Johan Timmermans, Laurence Van Melderen
Jan 1, 2013·Journal of Molecular Biology·Laura M Patterson-FortinTony Romeo
Nov 28, 2012·Trends in Microbiology·Jacob R Chambers, Karin Sauer
Oct 1, 2011·Environmental Microbiology·Joana A MoscosoAlain Filloux
Jun 8, 2012·Environmental Microbiology·Tony RomeoPaul Babitzke
Sep 24, 2013·The EMBO Journal·Torsten SterzenbachAndreas J Bäumler
Oct 7, 2015·Frontiers in Microbiology·Marc Erhardt, Petra Dersch
Aug 22, 2015·FEMS Microbiology Letters·Danitza N FuentesIván L Calderón
Sep 16, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andreas Diepold, Judith P Armitage
Apr 12, 2014·Frontiers in Cellular and Infection Microbiology·Luary C Martínez, Viveka Vadyvaloo
Aug 1, 2014·Frontiers in Cellular and Infection Microbiology·Kai Papenfort, Jörg Vogel
Aug 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sampriti MukherjeeDaniel B Kearns
Aug 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Florian AltegoerGert Bange
Nov 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yasuhiko IrieMatthew R Parsek
Feb 28, 2013·International Journal of Molecular Sciences·Franziska Mika, Regine Hengge

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