Complex Regulatory Role of the TRPA1 Receptor in Acute and Chronic Airway Inflammation Mouse Models.

International Journal of Molecular Sciences
Zsófia HajnaZsuzsanna Helyes

Abstract

The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and exogenous irritants, e.g., endotoxins, nicotine, crotonaldehyde and acrolein. We investigated its involvement in acute and chronic pulmonary inflammation using Trpa1 gene-deleted (Trpa1-/-) mice. Acute pneumonitis was evoked by intranasal Escherichia coli endotoxin (lipopolysaccharide: LPS) administration, chronic bronchitis by daily cigarette smoke exposure (CSE) for 4 months. Frequency, peak inspiratory/expiratory flows, minute ventilation determined by unrestrained whole-body plethysmography were significantly greater, while tidal volume, inspiratory/expiratory/relaxation times were smaller in Trpa1-/- mice. LPS-induced bronchial hyperreactivity, myeloperoxidase activity, frequency-decrease were significantly greater in Trpa1-/- mice. CSE significantly decreased tidal volume, minute ventilation, peak inspiratory/expiratory flows in wildtypes, but not in Trpa1-/- mice. CSE remarkably increased the mean linear intercept (histopathology), as an emphysema indicator after 2 months in wildtypes, but only after 4 months in Trpa1-/- mice. Semiquantitativ...Continue Reading

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Citations

Aug 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eszter CsikósGyörgyi Horváth
Apr 4, 2021·International Journal of Molecular Sciences·Alina Milici, Karel Talavera
Jul 25, 2021·Pulmonary Pharmacology & Therapeutics·Samu LuostarinenEeva Moilanen

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Methods Mentioned

BETA
bronchoalveolar lavage
PCR

Software Mentioned

GraphPad Prism
Case Viewer
ARRIVE
GraphPad

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