Complex Repetitive Discharges: A Sign of Motor Axonal Reinnervation?

Brain Sciences
Andreas PosaMalte E Kornhuber

Abstract

Complex repetitive discharges (CRDs) are poorly understood phenomena in needle electromyography (EMG) recordings. The data presented here suggest that CRDs may mainly be a sign of motor unit reinnervation. EMG "video" data of 108 CRDs from neurogenic (ND, n = 39) and myogenic (MD, n = 14) disorders were retrospectively analyzed for cycle duration, potential-free time intervals, spike components (SC), maximum amplitudes, blockade, and increased jitter. CRD-SC in ND disorders (9.3 ± 7.8) outnumbered those in MD disorders (6.3 ± 6.2). The CRD cycle duration was correlated with SC and silent periods (p each < 0.000001). Blockade was observed in 36% and increased jitter in 27% of the CRDs. A higher number of CRD-SC in ND vs. MD fits the known differences in motor unit dimensions. Blockade and increased jitter are known features of diseased neuromuscular junctions, such as during reinnervation. The SC patterns of single CRD cycles resemble reinnervation potentials. Thus, CRDs may result from myo-axonal re-excitation in sprouting motor units. The purpose of this investigation was to better understand the circumstances under which CRDs may occur and eventually to contribute to the understanding of their pathogenesis.

References

Feb 1, 1972·Journal of Neurology, Neurosurgery, and Psychiatry·E Stålberg, B Thiele
Apr 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·J Trontelj, E Stålberg
Feb 1, 1994·Electroencephalography and Clinical Neurophysiology·G Roth
Sep 1, 1996·Muscle & Nerve·D B Sanders, E V Stålberg
May 16, 1998·BMJ : British Medical Journal·T V Perneger
Sep 25, 2003·Muscle & Nerve·Lesley K FellowsColin H Chalk
Nov 1, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·João CostaMamede de Carvalho
Jan 16, 2009·Muscle & Nerve·Jasper R Daube, Devon I Rubin
Aug 26, 2009·Muscle & Nerve·Erik V Stålberg, Donald B Sanders
Jun 27, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Matthias GmeinerKurt Holl
Aug 15, 2017·Toxicon : Official Journal of the International Society on Toxinology·Mark Hallett
Dec 27, 2019·Muscle & Nerve·Andreas PosaMalte Kornhuber

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Citations

Dec 15, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Andrew Eisen, David Taylor

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Methods Mentioned

BETA
biopsy

Software Mentioned

Statistica
TOENNIES NeuroScreen
TOENNIES Multiliner

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