Complex segregation analysis with pointers

Human Heredity
J M Lalouel, N E Morton

Abstract

Complex segregation analysis has been extended to apply to nuclear families and relatives outside the nuclear family that have led to its ascertainment. These individuals are referred to as pointers. The mixed model of Morton and MacLean has been modified to allow for a sex-linked major gene, mutation, and generational differences in multifactorial transmission for adults and children, respectively. The model and methods used in implementing it are described, as well as the rationale underlying this approach to analysis of pedigree data.

Citations

Jul 1, 1990·American Journal of Medical Genetics·I B BoreckiJ M Lalouel
Dec 1, 1995·Human Genetics·M B RussellJ Olesen
Jan 1, 1982·Immunogenetics·H Z HoN E Morton
Jan 1, 1988·European Archives of Psychiatry and Neurological Sciences·H H StassenJ Angst
Dec 1, 1994·Diabetologia·M I McCarthyM Viswanathan
Dec 1, 1994·Diabetologia·J T CookR C Turner
Jan 1, 1984·Behavior Genetics·I B Borecki, G C Ashton
May 1, 1993·Behavior Genetics·B A LewisP J Byard
Jul 17, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Michael Bjørn Russell
Aug 15, 1993·Biological Psychiatry·E J Devor, R Waziri
Jun 1, 1982·Computers and Biomedical Research, an International Journal·S J Hasstedt
Oct 1, 1984·Computers and Biomedical Research, an International Journal·C J MacLeanS Yee
Nov 1, 1986·The Journal of Allergy and Clinical Immunology·M N BlumenthalR C Elston
Jun 1, 1988·Psychiatry Research·R A PriceE D Caine
Mar 31, 2004·Annales de génétique·Vincent GajdosCatherine Bonaïti-Pellié
Jul 25, 1997·Schizophrenia Research·A RuizA San Martín
Sep 1, 1991·Baillière's Clinical Endocrinology and Metabolism·S W Serjeantson, P Zimmet
Nov 9, 2000·BJU International·M K KarayiA F Markham
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·N E Morton
May 1, 1996·Ethnicity & Health·M T KailasamR J Parmer
Nov 14, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J M BlackwellM A Shaw
Jan 1, 1997·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M B Russell
Apr 2, 2010·Epilepsia·Rodrigo SecolinIscia Lopes-Cendes
Dec 1, 1982·Journal of Medical Genetics·L IseliusJ R Playfer
Jul 1, 1991·Journal of Medical Genetics·E R MaherN Morton
Aug 1, 1993·Journal of Medical Genetics·C M van DuijnA Hofman
Sep 9, 2000·Journal of Medical Genetics·C ChapmanR O Nicol
Mar 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·M B RussellL L Thomsen
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·N Simon ThomasS T Holgate
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gregory LivshitsEugene Kobyliansky
Mar 7, 2002·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Mary L MarazitaYou-e Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.