Complex spatiotemporal tuning in human upper-limb muscles

Journal of Neurophysiology
J Andrew PruszynskiStephen H Scott

Abstract

Correlations between neural activity in primary motor cortex (M1) and arm kinematics have recently been shown to be temporally extensive and spatially complex. These results provide a sophisticated account of M1 processing and suggest that M1 neurons encode high-level movement trajectories, termed "pathlets." However, interpreting pathlets is difficult because the mapping between M1 activity and arm kinematics is indirect: M1 activity can generate movement only via spinal circuitry and the substantial complexities of the musculoskeletal system. We hypothesized that filter-like complexities of the musculoskeletal system are sufficient to generate temporally extensive and spatially complex correlations between motor commands and arm kinematics. To test this hypothesis, we extended the computational and experimental method proposed for extracting pathlets from M1 activity to extract pathlets from muscle activity. Unlike M1 activity, it is clear that muscle activity does not encode arm kinematics. Accordingly, any spatiotemporal correlations in muscle pathlets can be attributed to musculoskeletal complexities rather than explicit higher-order representations. Our results demonstrate that extracting muscle pathlets is a robust and r...Continue Reading

References

Jul 1, 1976·Journal of Neurophysiology·P Bawa, R B Stein
Jan 1, 1985·Biological cybernetics·N Hogan
Oct 1, 1969·The Journal of Physiology·P M Rack, D R Westbury
Oct 1, 1980·Journal of Neurophysiology·P D Cheney, E E Fetz
Jan 1, 1982·Biological cybernetics·M J Hollerbach, T Flash
Apr 1, 1996·Journal of Muscle Research and Cell Motility·S H ScottG E Loeb
Nov 24, 1999·Journal of Neurophysiology·D W Moran, A B Schwartz
May 17, 2000·Journal of Muscle Research and Cell Motility·I E Brown, G E Loeb
Jun 14, 2002·Neuron·Michael S A GrazianoTirin Moore
Jun 28, 2002·Nature·Paul L Gribble, Stephen H Scott
Mar 4, 2003·Journal of Neurophysiology·Kirsten M GrahamStephen H Scott
Oct 10, 2006·Nature Neuroscience·Daichi NozakiStephen H Scott
Feb 3, 2007·Journal of Neurophysiology·Troy M HerterStephen H Scott
Mar 23, 2007·Journal of Neurophysiology·Mark M Churchland, Krishna V Shenoy
May 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicholas G HatsopoulosYali Amit
Sep 21, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J Andrew PruszynskiIsaac Kurtzer
May 9, 2008·Journal of Neurophysiology·J Andrew PruszynskiStephen H Scott
Nov 14, 2008·Journal of Neurophysiology·Troy M HerterStephen H Scott
May 15, 2009·Journal of Neurophysiology·J Andrew PruszynskiStephen H Scott

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Citations

Jan 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maryam SalehNicholas G Hatsopoulos
Nov 15, 2011·Neuron·Nicholas G Hatsopoulos, Aaron J Suminski
Feb 22, 2018·Journal of Neurophysiology·Gordon TaoGunnar Blohm
May 6, 2011·Journal of Neurophysiology·J Andrew PruszynskiStephen H Scott

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