PMID: 3746392Jul 1, 1986Paper

Complex-spike activity of cerebellar Purkinje cells related to wrist tracking movement in monkey

Journal of Neurophysiology
N ManoKenji Yamamoto

Abstract

Four rhesus monkeys were trained to perform visually guided wrist tracking movements (50). While they performed tasks by wrist flexion or extension from a neutral position, simple-spike (SS) and complex-spike (CS) discharges of a single Purkinje cell (P-cell) were recorded from intermediate and lateral parts of cerebellar hemispheres (lobules IV to VI) ipsilateral to the task-performing wrist. Of approximately 400 P-cells observed, 215 (54%) significantly increased or decreased their SS discharge rate during task performance (task-related P-cells). Of these, 161 were selected for analysis of CS activity; in these P-cells, we could reliably discriminate between CS and background SS by a spike discriminator. The 161 P-cells were further classified into response locked (n = 65) and poorly locked (n = 96) cells according to temporal coupling of the SS frequency modulation to the onset of wrist movements. About 60% of the response-locked P-cells showed a phasic increase (statistical significance level: P less than 0.01) of CS firing rate at the onset of wrist tracking movement. In a few P-cells, a phasic decrease (statistically insignificant) of CS firing rate was observed with the wrist movement. In most P-cells, an increase of CS ...Continue Reading

Citations

Sep 18, 1998·The Anatomical Record·J R Bloedel, V Bracha
Feb 13, 2003·Annals of the New York Academy of Sciences·Timothy J EbnerQinggong Fu
Dec 1, 1993·Journal of Neurology·H MitomaH Tsukagoshi
Sep 30, 1998·The European Journal of Neuroscience·N SchweighoferM Kawato
Aug 15, 2012·Biological cybernetics·Rodrigo Alvarez-Icaza, Kwabena Boahen
Sep 5, 2003·Journal of Neurophysiology·Robert S TurnerScott T Grafton
Feb 13, 2003·Annals of the New York Academy of Sciences·Matthew T SchmoleskyChristian Hansel
Jul 14, 2017·Journal of Neurophysiology·Martha L StrengTimothy J Ebner
Jul 10, 2018·The Cerebellum·Martha L StrengTimothy J Ebner
Dec 1, 1992·The Behavioral and Brain Sciences·J F Stein

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