Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number

BMC Neuroscience
Glenn D Rosen, Robert W Williams

Abstract

The striatum plays a pivotal role in modulating motor activity and higher cognitive function. We analyzed variation in striatal volume and neuron number in mice and initiated a complex trait analysis to discover polymorphic genes that modulate the structure of the basal ganglia. Brain weight, brain and striatal volume, neuron-packing density and number were estimated bilaterally using unbiased stereological procedures in five inbred strains (A/J, C57BL/6J, DBA/2J, BALB/cJ, and BXD5) and an F2 intercross between A/J and BXD5. Striatal volume ranged from 20 to 37 mm3. Neuron-packing density ranged from approximately 50,000 to 100,000 neurons/mm3, and the striatal neuron population ranged from 1.4 to 2.5 million. Inbred animals with larger brains had larger striata but lower neuron-packing density resulting in a narrow range of average neuron populations. In contrast, there was a strong positive correlation between volume and neuron number among intercross progeny. We mapped two quantitative trait loci (QTLs) with selective effects on striatal architecture. Bsc10a maps to the central region of Chr 10 (LRS of 17.5 near D10Mit186) and has intense effects on striatal volume and moderate effects on brain volume. Stnn19a maps to distal...Continue Reading

Citations

May 15, 2003·The Journal of Comparative Neurology·Corinna C Zygourakis, Glenn D Rosen
Sep 5, 2008·Neurological Research·Edalatmanesh Mohammad AminNeshati Zeinab
Mar 14, 2009·Experimental Brain Research·Jennifer Rodger, Douglas O Frost
Jan 11, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rebecca J YangAndrew Holmes
Feb 4, 2016·The European Journal of Neuroscience·Daniel J HegemanC Savio Chan
Nov 9, 2018·Frontiers in Neuroanatomy·Daniel KellerHenry Markram
Dec 1, 2005·Neuroreport·Elizabeth M Sajdel-SulkowskaMark G Baxter
Oct 31, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sara Ares-SantosRosario Moratalla
Jan 1, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Robert HitzemannShannon McWeeney
Sep 16, 2016·Proceedings. Biological Sciences·Stephen H MontgomeryRobert A Barton
Dec 21, 2004·Cytopathology : Official Journal of the British Society for Clinical Cytology·B VicandiJ M Viguer
Oct 2, 2012·EJNMMI Research·Miia PitkonenKim Bergström
Apr 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·J J Johannes HjorthSten Grillner
Jul 8, 2020·Scientific Data·Ingvild E BjerkeTrygve B Leergaard
Apr 23, 2008·Current Protocols in Neuroscience·Robert W WilliamsGlenn D Rosen
Jul 21, 2021·Neuroinformatics·J J Johannes HjorthAlexander Kozlov

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Methods Mentioned

BETA
transgenic
dissection
PCR
genotyping

Software Mentioned

Mouse Brain Library
MapManager
Map Manager
NIH Image
StrAnatData

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