Complex Walking Tasks and Risk for Cognitive Decline in High Functioning Older Adults

Journal of Alzheimer's Disease : JAD
Andrea L RossoCaterina Rosano

Abstract

Performance on complex walking tasks may provide a screen for future cognitive decline. To identify walking tasks that are most strongly associated with subsequent cognitive decline. Community-dwelling older adults with Modified Mini-Mental State (3MS) >85 at baseline (n = 223; mean age = 78.7, 52.5% women, 25.6% black) completed usual-pace walking and three complex walking tasks (fast-pace, narrow-path, visuospatial dual-task). Slope of 3MS scores for up to 9 subsequent years (average = 5.2) were used to calculate a cognitive maintainer (slope ≥0) or decliner (slope <0) outcome variable. Logistic regression models assessed associations between gait speeds and being a cognitive decliner. A sensitivity analysis in a subsample of individuals (n = 66) confirmed results with adjudicated mild cognitive impairment (MCI) or dementia at 8-9 years post-walking assessment. Cognitive decliners were 52.5% of the sample and on average were slower for all walking tasks compared to maintainers. In models adjusted for demographic and health variables, faster fast-pace (OR = 0.87 per 0.1 m/s, 95% CI: 0.78, 0.97) and dual-task (OR = 0.84 per 0.1 m/s, 95% CI: 0.73, 0.96) gait speeds were associated with lower likelihood of being a cognitive decli...Continue Reading

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Citations

Jul 19, 2019·Journal of the American Geriatrics Society·Andrea L RossoCaterina Rosano
Sep 3, 2019·Journal of Alzheimer's Disease : JAD·Manuel Montero-Odasso, George Perry
Jan 9, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Giulia GrandeLaura Fratiglioni
Apr 15, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Nemin ChenAndrea L Rosso
Mar 9, 2021·Frontiers in Aging Neuroscience·Naina Yuki Vieira JardimCristovam Wanderley Picanço Diniz
Jul 8, 2021·Journal of the American Geriatrics Society·Briana N SpragueCaterina Rosano
Jul 24, 2021·Journal of the American Geriatrics Society·Briana N SpragueCaterina Rosano
Jul 30, 2021·Journal of the American Geriatrics Society·Heather E WhitsonCathleen Colón-Emeric
Jul 6, 2020·Gerontology·Pedro Ángel Latorre RománJuan Antonio Párraga Montilla

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