Complexation and coacervation of like-charged polyelectrolytes inspired by mussels

Proceedings of the National Academy of Sciences of the United States of America
Sangsik KimDong Soo Hwang

Abstract

It is well known that polyelectrolyte complexes and coacervates can form on mixing oppositely charged polyelectrolytes in aqueous solutions, due to mainly electrostatic attraction between the oppositely charged polymers. Here, we report the first (to the best of our knowledge) complexation and coacervation of two positively charged polyelectrolytes, which provides a new paradigm for engineering strong, self-healing interactions between polyelectrolytes underwater and a new marine mussel-inspired underwater adhesion mechanism. Unlike the conventional complex coacervate, the like-charged coacervate is aggregated by strong short-range cation-π interactions by overcoming repulsive electrostatic interactions. The resultant phase of the like-charged coacervate comprises a thin and fragile polyelectrolyte framework and round and regular pores, implying a strong electrostatic correlation among the polyelectrolyte frameworks. The like-charged coacervate possesses a very low interfacial tension, which enables this highly positively charged coacervate to be applied to capture, carry, or encapsulate anionic biomolecules and particles with a broad range of applications.

References

Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·J P Gallivan, D A Dougherty
Aug 5, 1997·Chemical Reviews·Jennifer C. Ma, Dennis A. Dougherty
Jun 11, 2004·Biophysical Journal·Willem K Kegel, Paul van der Schoot Pv
Nov 25, 1949·Science·R M Fuoss, H Sadek
Dec 25, 2007·Nature Chemical Biology·Yi XueThomas V O'Halloran
Feb 1, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Antonio Siber, Rudolf Podgornik
Dec 2, 2008·Macromolecular Bioscience·Hui ShaoRussell J Stewart
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Zhen-Gang Wang
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hongbo ZengJ Herbert Waite
Mar 8, 2011·Advances in Colloid and Interface Science·Arthur Veis
May 6, 2011·Soft Matter·Dong Soo HwangJ Herbert Waite
Jun 28, 2011·Journal of Colloid and Interface Science·Jasper van der GuchtMartien A Cohen Stuart
Aug 2, 2011·Advances in Colloid and Interface Science·Ebru KizilayPaul L Dubin
Nov 8, 2011·Annual Review of Materials Research·Bruce P LeeJ H Waite
May 15, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Dimitrios PriftisMatthew Tirrell
Oct 23, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Dimitrios PriftisMatthew Tirrell
Mar 2, 2013·Angewandte Chemie·Qingye LuHongbo Zeng
Sep 26, 2013·Acta Biomaterialia·Wei WeiJ Herbert Waite
Oct 5, 2013·The Journal of Chemical Physics·Rui Wang, Zhen-Gang Wang
Jan 15, 2015·Nature Communications·Sarah L PerryMatthew Tirrell
Apr 16, 2015·Biofouling·Nadine R Martinez RodriguezJ Herbert Waite
Feb 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sangsik KimDong Soo Hwang

❮ Previous
Next ❯

Citations

Aug 9, 2016·Advances in Colloid and Interface Science·YongSeok JhoDong Soo Hwang
Nov 5, 2016·The Journal of Organic Chemistry·Shinji YamadaEri Takamori
Feb 2, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Kazi SadmanKenneth R Shull
May 26, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Yiran LiWei Wang
Jun 21, 2017·Soft Matter·Benxin JingYingxi Zhu
Feb 17, 2017·The Journal of Experimental Biology·J Herbert Waite
Jan 24, 2019·Macromolecular Rapid Communications·Xiangwei ZhuQiang Zhao
Jan 12, 2019·Annual Review of Food Science and Technology·Adeline BoirePaul Menut
Mar 28, 2019·Soft Matter·Whitney C Blocher McTigue, Sarah L Perry
Jul 27, 2018·The Journal of Biological Chemistry·Edward Gomes, James Shorter
Jun 7, 2019·Advanced Materials·Jingjie HuRahmi Oklu
Feb 1, 2020·Annual Review of Biophysics·Jeong-Mo ChoiRohit V Pappu
May 21, 2020·Macromolecular Rapid Communications·Lili ZhouChaobin He
Dec 6, 2016·Journal of Polymer Science. Part A, Polymer Chemistry·Pegah Kord Forooshani, Bruce P Lee
Oct 3, 2020·Small·Qiongyao PengHongbo Zeng
Jan 1, 2018·The Journal of Chemical Physics·Alexandros Chremos, Jack F Douglas
Apr 10, 2019·Polymers·Vikramjit S RatheeJonathan K Whitmer
Aug 23, 2020·Pharmaceutics·Amir Nasrolahi ShiraziRakesh Kumar Tiwari
Nov 5, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Whitney C Blocher, Sarah L Perry
Feb 10, 2018·ELife·Robert McCoy VernonJulie Deborah Forman-Kay
Nov 18, 2017·Soft Matter·Mintai P HwangYadong Wang
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sovan Lal BanerjeeNikhil K Singha
Sep 2, 2020·International Journal of Molecular Sciences·Greta BianchiStefania Brocca
Oct 21, 2020·Emerging Topics in Life Sciences·Erik W Martin, Alex S Holehouse
Nov 24, 2020·Physical Chemistry Chemical Physics : PCCP·Giacomo PrampoliniAlessandro Ferretti
Feb 4, 2021·ACS Applied Materials & Interfaces·Jaemin HwangJin Woong Kim
Sep 19, 2018·International Journal of Biological Macromolecules·Pankaj Kumar PandeyH B Bohidar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.