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Complexation in formulation of parenteral solutions: solubilization of the cytotoxic agent hexamethylmelamine by complexation with gentisic acid species

Journal of Pharmaceutical Sciences

Nov 1, 1975

B KreilgårdA J Repta

PMID: 483

Abstract

The apparent solubility of hexamethylmelamine in aqueous solutions suitable for intravenous use was increased by complexation with gentisic acid. Studies were carried out in the pH 0-8 range. Unprotonated hexamethylmelamine did not form complexes with the gentisate ion, while the hexame...read more

Mentioned in this Paper

Hydrogen-Ion Concentration
Hexinawas
Benzotriazines
Oxidation-Reduction
Drug Formulation Process
Quaternary Ammonium Compounds
Osmolality
Drug Stability
Gentisates
Paper Details
References

Complexation in formulation of parenteral solutions: solubilization of the cytotoxic agent hexamethylmelamine by complexation with gentisic acid species

Journal of Pharmaceutical Sciences

Nov 1, 1975

B KreilgårdA J Repta

PMID: 483

DOI:

Abstract

The apparent solubility of hexamethylmelamine in aqueous solutions suitable for intravenous use was increased by complexation with gentisic acid. Studies were carried out in the pH 0-8 range. Unprotonated hexamethylmelamine did not form complexes with the gentisate ion, while the hexame...read more

Mentioned in this Paper

Hydrogen-Ion Concentration
Hexinawas
Benzotriazines
Oxidation-Reduction
Drug Formulation Process
Quaternary Ammonium Compounds
Osmolality
Drug Stability
Gentisates

Related Papers

Paper Details
References
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