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Complexation in formulation of parenteral solutions: solubilization of the cytotoxic agent hexamethylmelamine by complexation with gentisic acid species

Journal of Pharmaceutical Sciences

Nov 1, 1975

B KreilgårdArnold J Repta

PMID: 483

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Abstract

The apparent solubility of hexamethylmelamine in aqueous solutions suitable for intravenous use was increased by complexation with gentisic acid. Studies were carried out in the pH 0-8 range. Unprotonated hexamethylmelamine did not form complexes with the gentisate ion, while the hexame...read more

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  • Complexation in formulation of parenteral solutions: solubilization of the cytotoxic agent hexamethylmelamine by complexation with gentisic acid species

    Journal of Pharmaceutical Sciences

    Nov 1, 1975

    B KreilgårdArnold J Repta

    PMID: 483

    DOI:

    Abstract

    The apparent solubility of hexamethylmelamine in aqueous solutions suitable for intravenous use was increased by complexation with gentisic acid. Studies were carried out in the pH 0-8 range. Unprotonated hexamethylmelamine did not form complexes with the gentisate ion, while the hexame...read more

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