Complexation-induced resolution enhancement of 3D-printed hydrogel constructs.

Nature Communications
Jiaxing GongYu Shrike Zhang

Abstract

Three-dimensional (3D) hydrogel printing enables production of volumetric architectures containing desired structures using programmed automation processes. Our study reports a unique method of resolution enhancement purely relying on post-printing treatment of hydrogel constructs. By immersing a 3D-printed patterned hydrogel consisting of a hydrophilic polyionic polymer network in a solution of polyions of the opposite net charge, shrinking can rapidly occur resulting in various degrees of reduced dimensions comparing to the original pattern. This phenomenon, caused by complex coacervation and water expulsion, enables us to reduce linear dimensions of printed constructs while maintaining cytocompatible conditions in a cell type-dependent manner. We anticipate our shrinking printing technology to find widespread applications in promoting the current 3D printing capacities for generating higher-resolution hydrogel-based structures without necessarily having to involve complex hardware upgrades or other printing parameter alterations.

References

Nov 17, 2001·Biomacromolecules·A I Van Den BulckeH Berghmans
Dec 16, 2005·Nature·Kari AlitaloTatiana V Petrova
Jun 4, 2010·Biomacromolecules·Yuan LiWillem Norde
Mar 12, 2011·Advanced Materials·Jason A Burdick, Glenn D Prestwich
May 20, 2011·Nature·Peter Carmeliet, Rakesh K Jain
Jun 28, 2011·Journal of Colloid and Interface Science·Jasper van der GuchtMartien A Cohen Stuart
Nov 30, 2011·Progress in Polymer Science·Kuen Yong Lee, David J Mooney
Mar 6, 2013·Biofabrication·Yahui ZhangIbrahim T Ozbolat
Sep 17, 2013·Advanced Materials·Jos MaldaDietmar W Hutmacher
Jan 1, 2012·Journal of Functional Biomaterials·Susana RodriguesAna Grenha
Aug 6, 2014·Nature Biotechnology·Sean V Murphy, Anthony Atala
Jan 17, 2015·Science·Fei ChenEdward S Boyden
Apr 29, 2015·Nature Communications·Jetze VisserJos Malda
Jul 17, 2015·Advanced Materials·Christopher B HighleyJason A Burdick
Oct 13, 2015·Nature Biotechnology·Ryuji MorizaneJoseph V Bonventre
Mar 10, 2016·Proceedings of the National Academy of Sciences of the United States of America·David B KoleskyJennifer A Lewis
Aug 10, 2016·Scientific Reports·Hitomi ShirahamaNam-Joon Cho
Aug 24, 2016·Biomaterials·Weitao JiaAli Khademhosseini
Oct 19, 2016·Lab on a Chip·Yu Shrike ZhangRahmi Oklu
Jan 15, 2017·Acta Biomaterialia·Pallab DattaIbrahim T Ozbolat
Sep 22, 2017·Biomacromolecules·Priyanka Sahariah, Már Másson
Aug 24, 2018·Advanced Materials·Qingmeng PiYu Shrike Zhang
Mar 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Neil Y C LinJennifer A Lewis
May 14, 2019·Lab on a Chip·Amir K MiriYu Shrike Zhang
Jun 22, 2019·Nature Reviews. Materials·Lorenzo MoroniJames J Yoo
Nov 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Eva HochKirsten Borchers
Apr 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuangcheng TangWei He

❮ Previous
Next ❯

Citations

Oct 20, 2020·Advanced Healthcare Materials·Liang MaHuayong Yang
Oct 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yong HuShenqiang Ren
Nov 13, 2020·Stem Cells Translational Medicine·Kai ZhuChunsheng Wang
Apr 12, 2020·Methods : a Companion to Methods in Enzymology·Tingting LiuYu Shrike Zhang
Jan 16, 2021·Advanced Materials·Haodong LiuWei Huang
Jan 16, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Wei GaoYongping Chen
Feb 11, 2021·APL Bioengineering·Megan E Cooke, Derek H Rosenzweig
Jan 29, 2021·IScience·Sajjad Rahmani DabbaghSavas Tasoglu
Jan 12, 2021·Bio-design and Manufacturing·Pengju WangHaitao Liu
Mar 13, 2021·International Journal of Biological Macromolecules·Aatrayee DasArup Mukherjee
Sep 21, 2020·Trends in Biotechnology·Abhishek P DhandJason A Burdick
Jan 7, 2021·ACS Applied Materials & Interfaces·Yue WangLijie Grace Zhang
May 4, 2021·Advanced Materials·Chihyeong WonTaeyoon Lee
Jun 18, 2021·Advanced Healthcare Materials·Mian WangYu Shrike Zhang
Jul 20, 2021·Advanced Materials·Wanlu LiYu Shrike Zhang
Jul 24, 2021·Advanced Healthcare Materials·Hyeonji YuJungwook Kim
Aug 10, 2021·Biomicrofluidics·Duilia N du ChatinierYu Shrike Zhang
Aug 29, 2020·Chemical Reviews·Andrea SchwabJos Malda
Sep 25, 2021·Advanced Healthcare Materials·Di WuYu Shrike Zhang
Sep 29, 2021·ACS Biomaterials Science & Engineering·Weijian HuaYifei Jin
Oct 6, 2021·Advanced Materials·Mian WangYu Shrike Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
confocal microscopy
bioprinting
biopsy

Software Mentioned

Matlab
imageJ
Matlab function im2bw

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

JAMA Otolaryngology-- Head & Neck Surgery
Kyle K VanKoeveringGlenn E Green
Health Services Journal
Matt DexterKeith Grimes
© 2021 Meta ULC. All rights reserved