Complexation of tocotrienol with gamma-cyclodextrin enhances intestinal absorption of tocotrienol in rats

Bioscience, Biotechnology, and Biochemistry
Saiko IkedaTomohiro Yano

Abstract

To determine the bioavailability of tocotrienol complex with gamma-cyclodextrin, the effects of tocotrienol/gamma-cyclodextrin complex on tocotrienol concentration in rat plasma and tissues were studied. Rats were administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. At 3 h after administration, the plasma gamma-tocotrienol concentration of the rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the rats administered tocotrienol and gamma-cyclodextrin. In order to determine the effect of complexation on tocotrienol absorption, rats were injected with Triton WR1339, which prevents the catabolism of triacylglycerol-rich lipoprotein by lipoprotein lipase, and then administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. The plasma gamma-tocotrienol concentration of the Triton-treated rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the other Triton-treated rats. These results suggest that complexation of tocotrienol with gamma-cyclodextrin elevates plasma and tissue tocotrienol concentrations by e...Continue Reading

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Citations

Jul 25, 2012·Therapeutic Delivery·Christine Dufès
Oct 27, 2015·International Journal of Molecular Sciences·Naoko IkutaSeiichi Matsugo
Nov 12, 2014·International Journal of Molecular Sciences·Naoko IkutaSeiichi Matsugo
Feb 16, 2016·Journal of Nutritional Science and Vitaminology·Ryosuke SugaharaTomohiro Yano
Oct 27, 2012·Ageing Research Reviews·I M A ErnstG Rimbach
Feb 17, 2017·European Journal of Nutrition·Martin PurpuraValentina Razmovski-Naumovski
Jun 4, 2019·Biological & Pharmaceutical Bulletin·Ayami SatoTomohiro Yano
Dec 17, 2020·International Journal of Nanomedicine·Anis Syauqina Mohd ZaffarinEkram Alias
Apr 4, 2021·Biomolecules·Svenja WüpperGerald Rimbach
Feb 5, 2011·The Journal of Nutritional Biochemistry·Noriyuki MiyoshiHiroshi Ohshima

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