Complexation with C60 Fullerene Increases Doxorubicin Efficiency against Leukemic Cells In Vitro

Nanoscale Research Letters
A GrebinykM Frohme

Abstract

Conventional anticancer chemotherapy is limited because of severe side effects as well as a quickly evolving multidrug resistance of the tumor cells. To address this problem, we have explored a C60 fullerene-based nanosized system as a carrier for anticancer drugs for an optimized drug delivery to leukemic cells.Here, we studied the physicochemical properties and anticancer activity of C60 fullerene noncovalent complexes with the commonly used anticancer drug doxorubicin. C60-Doxorubicin complexes in a ratio 1:1 and 2:1 were characterized with UV/Vis spectrometry, dynamic light scattering, and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The obtained analytical data indicated that the 140-nm complexes were stable and could be used for biological applications. In leukemic cell lines (CCRF-CEM, Jurkat, THP1 and Molt-16), the nanocomplexes revealed ≤ 3.5 higher cytotoxic potential in comparison with the free drug in a range of nanomolar concentrations. Also, the intracellular drug's level evidenced C60 fullerene considerable nanocarrier function.The results of this study indicated that C60 fullerene-based delivery nanocomplexes had a potential value for optimization of doxorubicin efficiency agains...Continue Reading

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Citations

Jun 17, 2020·Chemical Society Reviews·Saeid KargozarMasoud Mozafari
Nov 9, 2019·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Nechat Sumi, Kumari Chidambaran Chitra
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lianjie YeMeilan Yu
Aug 11, 2021·The Journal of Physical Chemistry. B·Vladimir V SharoykoKonstantin N Semenov

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Methods Mentioned

BETA
Fluorescence
dynamic light scattering
flow cytometry
FACS
fluorescence microscopy

Software Mentioned

GraphPad
GraphPad Prism
Keyence BZ - II Viewer
BD

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