Complexation with phosphatidyl choline as a strategy for absorption enhancement of boswellic acid

Drug Delivery
Amrita SharmaVinod Kumar Dixit

Abstract

Boswellic acids (BAs) are isolated from oleo gum resin of Boswellia serrata and are reported to be effective as anti-inflammatory, hypolipidemic, immunomodulatory, and anti-tumor. Pharmacokinetic studies of boswellic acid reveal its poor absorption through the intestine. The objective of the present study is to enhance bioavailability of boswellic acid by its complexation with phosphatidylcholine. A complex of boswellic acid was prepared with phosphatidylcholine and characterized on the basis of solubility, melting point, TLC, and IR. An everted intestine sac technique was used to study ex-vivo drug absorption of boswellic acid-phosphatidylcholine (BA-PC) complex and plain boswellic acid. Anti-inflammatory activity of the complex was compared with boswellic acid in carrageenan-induced paw edema in rats. Hypolipidemic activity was also evaluated in Triton-induced hyperlipidemia. The complex was also converted into vesicles (phytosomes) and compared with other vesicular systems (liposomes and niosomes) by evaluating its anti-inflammatory effect. Analytical reports along with spectroscopic data revealed the formation of a complex. The results of ex-vivo study show that BA-PC complex has significantly increased absorption compared ...Continue Reading

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Citations

Nov 19, 2010·Archives of Dermatological Research·Nishant Kumar Gupta, V K Dixit
Dec 14, 2011·Archives of Dermatological Research·Kirti UpadhyayVinod Kumar Dixit
Dec 4, 2013·Journal of Agricultural and Food Chemistry·Urszula LewandowskaSylwia Gorlach
Mar 20, 2013·Journal of Liposome Research·Pushpendra Kumar JainMurli Dhar Kharya
Dec 30, 2011·Drug Development and Industrial Pharmacy·Kirti UpadhyayVinod Kumar Dixit
Nov 22, 2012·Drug Development and Industrial Pharmacy·Pushpendra Kumar JainAsmita Gajbhiye
Sep 14, 2012·Expert Opinion on Drug Delivery·Chandana MohantySanjeeb K Sahoo
Mar 5, 2011·Journal of Pharmaceutical Sciences·Nishant Kumar Gupta, Vinod Kumar Dixit
Feb 18, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yosra S R ElnaggarOssama Y Abdallah
Jan 2, 2021·Frontiers in Pharmacology·K Reeta VijayaraniMuralikrishnan Dhanasekaran

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