Complexes of tetracyclines with divalent metal cations investigated by stationary and femtosecond-pulsed techniques

Physical Chemistry Chemical Physics : PCCP
Benedetta CarlottiFausto Elisei

Abstract

Spectroscopic techniques both in steady-state (in absorption and emission) and pulsed (absorption of excited states with femtosecond resolution) conditions were used to study the complexation process between six molecules belonging to the tetracycline family and Mg(2+); in the case of TC the study was extended to the metal ions Ca(2+) and Cu(2+). The study was carried out in aqueous solution at various pH values, where one acid-base form of the substrate prevails over the others. The processing of experimental results, performed by means of Singular Value Decomposition and Global Analysis methods, allowed us to evaluate the extent of interaction through the association constants, to identify the number of equilibria present in solution and the stoichiometry (1:1 or 1:2) of the tetracycline:metal ion complex, and to define the spectral and photophysical properties of the latter (in terms of fluorescence quantum yields, lifetimes and rate constants). In fact, the (allowed) radiative decay process is a minor root for the lowest excited state of the complexes which mainly decay to the ground state by internal conversion. Details of the complexation sites are proposed for the various protonated forms of tetracyclines, and for the va...Continue Reading

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Jul 28, 2010·Physical Chemistry Chemical Physics : PCCP·Benedetta CarlottiFausto Elisei

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Citations

Jun 6, 2014·Physical Chemistry Chemical Physics : PCCP·Benedetta CarlottiVincenzo Barone
Sep 25, 2014·Physical Chemistry Chemical Physics : PCCP·A CesarettiF Elisei
Aug 23, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Giuliano PizzoliFilippo De Angelis
Mar 17, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·A CesarettiF Elisei
Dec 19, 2013·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Alessio CesarettiFausto Elisei
Sep 19, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·P Raspor LainščekA Kirbiš
Sep 8, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Khaled El HawariEric Verdon
Apr 18, 2014·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Alessandra MazzoliAnna Spalletti
Dec 24, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yukiko MoriiwaAkio Yanagida
Sep 5, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Khaled El HawariMohamad Al Iskandarani
Jun 9, 2015·Journal of Neural Engineering·Zhiling ZhangYinghui Zhong
Feb 6, 2017·Physical Chemistry Chemical Physics : PCCP·A CesarettiA Spalletti
Mar 30, 2021·Journal of Analytical Methods in Chemistry·Hong Anh DuongHung Viet Pham
Jul 26, 2019·The Science of the Total Environment·Ngoc Han TranKarina Yew-Hoong Gin
Aug 7, 2021·Biosensors·Magdalena R RaykovaAndrew C Ward

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