Nov 10, 1977

Complexing Rauscher leukemia virus reverse transcriptase with human plasma ribonuclease from Hodgkin's disease patients

The Journal of Biological Chemistry
A K BandyopadhyayM R Mardiney

Abstract

Human ribonucleases were purified from the sera of Hodgkin's disease patients by sequential column chromatography. The purified enzyme interacted with reverse transcriptase of Rauscher leukemia virus and formed an additive complex of Mr = 130,000. RNase and oligo(dG)-directed reverse transcriptase activities were diminished in the complex. The complex could be dissociated with the subsequent restoration of both activities in the presence of spermidine. The molecular weight of the complex suggest that the 2 RNase molecules bind to a single reverse transcriptase molecule.

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Mentioned in this Paper

Human plasma
Rauscher Virus
Phosphoglycerate Dehydrogenase Activity
Alkaline Ribonuclease
Pancreatic ribonuclease
PHGDH wt Allele
Oligonucleotides
Hodgkin Disease
Leukemia
Serum

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