PMID: 11927285Apr 3, 2002Paper

Complexities in the development of cyclin-dependent kinase inhibitor drugs

Trends in Molecular Medicine
Edward A Sausville

Abstract

Abnormalities in the normal regulation of the cell cycle are a hallmark of neoplasia. Drugs directed against the cyclin-dependent kinases (CDKs), which govern the normal orderly progression through the cell cycle, have been proposed to address the pathogenic defect in tumors. Recently, CDK family members that do not regulate the cell cycle directly but instead influence transcription (CDK7, CDK8, and CDK9) and neuronal and secretory cell function (CDK5) have been described. Continued synthetic chemistry efforts have defined important new selective inhibitors of CDKs, and strategies directed at newly described CDK-related targets, such as transcription control, can now be envisaged. CDKs remain important and novel targets whose potential needs to be more fully explored, albeit in light of the newly emerging complexities of their cellular physiology.

References

Nov 18, 1992·Journal of the National Cancer Institute·G KaurE Sausville
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S K Hanks
Mar 9, 1995·Nature·D O Morgan
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·X GrañaA Giordano
Oct 25, 1996·The Journal of Biological Chemistry·N F MarshallD H Price
Jan 1, 1997·Annual Review of Cell and Developmental Biology·D O Morgan
Apr 16, 1998·Genes & Development·J PengD H Price
Aug 8, 1998·Genes & Development·N Dyson
Oct 29, 1998·The Journal of Biological Chemistry·R C Muise-HelmericksN Rosen
Jan 1, 1999·Bioorganic & Medicinal Chemistry Letters·S SasakiM Maeda
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y N ChenW G Kaelin
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ShtutmanA Ben-Ze'ev
Jul 1, 1999·Genes & Development·C J Sherr, J M Roberts
Mar 4, 2000·Journal of the National Cancer Institute·A M Senderowicz, E A Sausville
Jun 17, 2000·Trends in Cell Biology·M J O'ConnellA M Carr
Jul 25, 2000·Journal of the National Cancer Institute·Z Darzynkiewicz
Jul 25, 2000·The Journal of Biological Chemistry·S H ChaoD H Price
Jul 27, 2000·Annals of the New York Academy of Sciences·E A SausvilleA M Senderowicz
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·V M RichonP A Marks
Feb 13, 2001·Trends in Cell Biology·D McCollum, K L Gould
Mar 22, 2001·Journal of the National Cancer Institute·R SoniB Chaudhuri
Jun 30, 2001·The Journal of Biological Chemistry·S H Chao, D H Price
Jul 10, 2001·The Journal of Biological Chemistry·L LiljaC Bark
Aug 22, 2001·Bioorganic & Medicinal Chemistry Letters·D J CariniT M Sielecki
Oct 19, 2001·Medicinal Research Reviews·P L Toogood

❮ Previous
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Citations

Mar 6, 2009·Investigational New Drugs·Ivan Diaz-PadillaIgnacio Duran
Feb 19, 2011·Investigational New Drugs·Xiangrui LiuShudong Wang
Apr 1, 2008·Current Hematologic Malignancy Reports·Xavier Thomas
Jun 16, 2009·Neurotoxicity Research·Bogdan A StoicaAlan I Faden
Mar 15, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·David R Newell
Nov 5, 2003·Progress in Cell Cycle Research·Peter M FischerLaurent Meijer
Feb 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Youzhi LiChiang J Li
Aug 27, 2002·Annual Review of Pharmacology and Toxicology·Edward A SausvilleGeorge Kim
Jul 26, 2012·Bioinformation·Nallusamy Saranya, Samuel Selvaraj
Nov 12, 2013·Apoptosis : an International Journal on Programmed Cell Death·Jirka GrosseDaniela Grimm
Dec 24, 2013·Pharmacology & Therapeutics·Todd M PittsErica L Bradshaw-Pierce
Jul 24, 2015·International Journal of Oncology·T MahgoubJ Crown
Jan 30, 2013·Pharmacology & Therapeutics·Santiago Diaz-MoralliMarta Cascante
Dec 16, 2006·Journal of Molecular Biology·Kyuwon BaekJohn A A Ladias
Apr 5, 2008·International Journal of Cancer. Journal International Du Cancer·Jia-Ren LiuBao-Feng Yang
Nov 28, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rachel C SkirrowCaren C Helbing
Jun 18, 2011·Biotechnology Journal·Bing ZhangVincent B C Tan
Oct 11, 2003·Biochemical and Biophysical Research Communications·Deborah J MoshinskyAudie G Rice
May 20, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jing LiuXiao-Zhong Wang
Feb 19, 2004·Seminars in Oncology·Henning Schulze-Bergkamen, Peter H Krammer
Sep 27, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Matteo SimoneMaurizio D'Incalci
Jul 5, 2005·Bioorganic & Medicinal Chemistry·Libor HavlicekMiroslav Strnad
Apr 1, 2007·Expert Opinion on Drug Discovery·Timothy A YapS de Bono
Jun 5, 2003·Expert Opinion on Investigational Drugs·Peter M Fischer, Athos Gianella-Borradori
Mar 1, 2012·Cancer Biology & Therapy·Miriam CanaveseNoopur Raje
Sep 3, 2002·Cancer Cell·Charles J Sherr, Frank McCormick
Aug 2, 2002·Cancer Cell·Daniel S O'ConnorDario C Altieri
Feb 24, 2006·Chemistry & Biology·George KontopidisPeter M Fischer
Aug 19, 2016·Acta Crystallographica. Section E, Crystallographic Communications·Wei GuoJing Wang
May 6, 2004·Bioorganic & Medicinal Chemistry Letters·Raj N MisraKevin R Webster

❮ Previous
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