PMID: 11917159Mar 28, 2002Paper

Complexities of cancer research: mouse genetic models

ILAR Journal
Kent W Hunter, Robert W Williams

Abstract

Cancer susceptibility is a complex interaction of an individual's genetic composition and environmental exposures. Huge strides have been made in understanding cancer over the past 100 yr, from recognition of cancer as a genetic disease, to identification of specific carcinogens, isolation of oncogenes, and recognition of tumor suppressors. A tremendous amount of knowledge has accumulated about the etiology of cancer. Cancer genetics has played a significant role in these discoveries. Analysis of high-risk familial cancers has led to the discovery of new tumor suppressor genes and important cancer pathways. These families, however, represent only a small fraction of cancer in the general population. Most cancer is instead probably the result of an intricate interaction of polymorphic susceptibility genes with the sea of environmental exposures that humans experience. Although the central cadre of cancer genes is known, little is understood about the peripheral genes that likely comprise the polymorphic susceptibility loci. The challenge for cancer genetics is therefore to move forward from the mendelian genetics of the rare familial cancer syndromes into the field of quantitative trait loci, susceptibility factors, and modifier...Continue Reading

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Citations

Jun 19, 2003·Journal of the National Cancer Institute·Danny R Welch, Kent W Hunter
Sep 2, 2008·Annual Review of Genetics·Kent W Hunter, Nigel P S Crawford
Aug 28, 2010·Veterinary Medicine International·Veronica MarchettiGiovanni Cardini
Feb 12, 2008·Otolaryngologia polska. The Polish otolaryngology·Andrzej WojdasJarosław Kosek
Feb 10, 2018·Nature Reviews. Cancer·Kent W HunterLalage Wakefield

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