Complexity and diversity of hepatitis C virus RNA in african americans and whites: analysis of the envelope-coding domain

The Journal of Infectious Diseases
Erica D KeenanKenneth E Sherman

Abstract

African Americans infected with hepatitis C virus (HCV) are less responsive than whites to interferon-based therapy. HCV quasi species have been implicated. Quasi-species complexity and diversity were evaluated in matched African American and white individuals. Complexity and diversity in the first hypervariable region were similar in the 2 groups. Both the frequency of nonsynonymous amino acid substitutions and the mean ratio of nonsynonymous mutations to synonymous mutations were greater in clones derived from white patients. Racial differences in amino acid usage at otherwise conserved positions were observed. Differences in amino acid representation at key positions are suggestive of immunologic and functional selection along racial lines.

Citations

Sep 5, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Dale M NetskiRobert S Klein
Oct 16, 2007·Digestive Diseases and Sciences·Nyingi Kemmer, Guy W Neff
Mar 25, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jamie C MandacYaron Tomer

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