Complexity generation during natural product biosynthesis using redox enzymes.

Current Opinion in Chemical Biology
Peng WangYi Tang

Abstract

Redox enzymes such as FAD-dependent and cytochrome P450 oxygenases play indispensible roles in generating structural complexity during natural product biosynthesis. In the pre-assembly steps, redox enzymes can convert garden variety primary metabolites into unique starter and extender building blocks. In the post-assembly tailoring steps, redox cascades can transform nascent scaffolds into structurally complex final products. In this review, we will discuss several recently characterized redox enzymes in the biosynthesis of polyketides and nonribosomal peptides.

References

Jun 28, 2003·Natural Product Reports·Dirk SchwarzerMohamed A Marahiel
Jun 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tobias J ErbBirgit E Alber
Jan 24, 2008·Chembiochem : a European Journal of Chemical Biology·Matthias StriekerMohamed A Marahiel
Apr 15, 2008·Angewandte Chemie·Alessandra S Eustáquio, Bradley S Moore
Jan 30, 2009·Journal of the American Chemical Society·Zeynep YuntJörn Piel
Apr 21, 2009·Natural Product Reports·Yolande A ChanMichael G Thomas
Apr 24, 2009·Chembiochem : a European Journal of Chemical Biology·Madan Kumar KharelJürgen Rohr
May 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tobias J ErbBirgit E Alber
Jun 11, 2009·Angewandte Chemie·Christian Hertweck
Jul 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alessandra S EustáquioBradley S Moore
May 11, 2010·Nature Chemical Biology·Kento KoketsuHideaki Oikawa
May 13, 2011·The Journal of Biological Chemistry·Nicholas NoinajJürgen Rohr
May 28, 2011·Biochemistry·Wenjun ZhangChristopher T Walsh
Jun 7, 2011·Nature Chemical Biology·Shunji TakahashiHiroyuki Osada
Jun 21, 2011·Journal of the American Chemical Society·Danny YunCatherine L Drennan
Jul 23, 2011·Nature Chemistry·Jacob C CarlsonDavid H Sherman
Dec 22, 2011·Natural Product Reports·Madan K KharelJürgen Rohr
Dec 23, 2011·Journal of the American Chemical Society·Shengying LiDavid H Sherman
Jan 1, 2011·Annual Review of Chemical and Biomolecular Engineering·Lauren B PickensYit-Heng Chooi

❮ Previous
Next ❯

Citations

Oct 15, 2013·Nature Chemical Biology·Yuta TsunematsuKenji Watanabe
Jul 17, 2013·Current Opinion in Chemical Biology·Michio SatoKenji Watanabe
Apr 8, 2017·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Shinji KishimotoKenji Watanabe
Jun 18, 2017·Archives of Biochemistry and Biophysics·Robin Teufel
Aug 5, 2017·Natural Product Reports·Xingwang Zhang, Shengying Li
Jul 22, 2014·Angewandte Chemie·Hülya AldemirTobias A M Gulder
Dec 18, 2018·Organic & Biomolecular Chemistry·Takahiro MasuyaKenji Watanabe
Oct 16, 2020·Natural Product Reports·P D WalkerM P Crump
Apr 25, 2013·Journal of the American Chemical Society·Kan'ichiro IshiuchiKenji Watanabe
Nov 5, 2013·ACS Chemical Biology·Matthew L HillwigXinyu Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.