Complexity in disease management: A linked data analysis of multimorbidity in Aboriginal and non-Aboriginal patients hospitalised with atherothrombotic disease in Western Australia

PloS One
Mohammad Akhtar HussainS C Thompson


Hospitalisation for atherothrombotic disease (ATD) is expected to rise in coming decades. However, increasingly, associated comorbidities impose challenges in managing patients and deciding appropriate secondary prevention. We investigated the prevalence and pattern of multimorbidity (presence of two or more chronic conditions) in Aboriginal and non-Aboriginal Western Australian residents with ATDs. We used population-based de-identified linked administrative health data from 1 January 2000 to 30 June 2014 to identify a cohort of patients aged 25-59 years admitted to Western Australian hospitals with a discharge diagnosis of ATD. The prevalence of common chronic diseases in these patients was estimated and the patterns of comorbidities and multimorbidities empirically explored using two different approaches: identification of the most commonly occurring pairs and triplets of comorbid diseases, and through latent class analysis (LCA). Half of the cohort had multimorbidity, although this was much higher in Aboriginal people (Aboriginal: 79.2% vs. non-Aboriginal: 39.3%). Only a quarter were without any documented comorbidities. Hypertension, diabetes, alcohol abuse disorders and acid peptic diseases were the leading comorbidities ...Continue Reading


Nov 26, 1998·The British Journal of Psychiatry : the Journal of Mental Science·C WallaceC Browne
Nov 27, 1999·Australian and New Zealand Journal of Public Health·C D HolmanM S Hobbs
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Paola PisaniD Maxwell Parkin
Aug 13, 2003·International Journal of Epidemiology·Kate J BrameldMichael Hobbs
Sep 24, 2004·Health and Quality of Life Outcomes·Martin FortinDanielle Maltais
Aug 11, 2005·JAMA : the Journal of the American Medical Association·Cynthia M BoydAlbert W Wu
Sep 20, 2005·Journal of Clinical Epidemiology·Julie E BylesCarla Treloar
Jul 22, 2008·The Medical Journal of Australia·Helena C BrittStephanie A Knox
Nov 5, 2008·Australian Health Review : a Publication of the Australian Hospital Association·C D'Arcy J HolmanFiona J Stanley
Feb 12, 2009·Journal of the American Geriatrics Society·Alessandra MarengoniLaura Fratiglioni
Jan 1, 2007·Structural Equation Modeling : a Multidisciplinary Journal·Stephanie T LanzaJoseph L Schafer
Jul 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Vera A Morgan, Assen V Jablensky
Jul 14, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Scott T Wilber, Rongwei Fu
Mar 16, 2011·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Chris SalisburyAlan A Montgomery
Apr 16, 2011·Stroke; a Journal of Cerebral Circulation·Judith M KatzenellenbogenJames P Codde
Jun 4, 2011·Population Health Metrics·Libby HoldenHarvey A Whiteford
Jul 26, 2011·International Journal of Cardiology·Thomas G BriffaMichael Hobbs
Aug 5, 2011·Medical Care Research and Review : MCRR·Thomas LehnertHans-Helmut König
Nov 20, 2012·BMC Medical Informatics and Decision Making·S C ThompsonJudith M Katzenellenbogen
Aug 22, 2013·Australian Health Review : a Publication of the Australian Hospital Association·Emily R AtkinsTom Briffa
Jan 30, 2014·Journal of Clinical Epidemiology·Alexandra Prados-TorresMarjan van den Akker
Apr 15, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Judith M KatzenellenbogenS C Thompson
Jun 26, 2014·Australian and New Zealand Journal of Public Health·Tanya MatherRosemary J Korda
Oct 12, 2014·European Journal of Preventive Cardiology·Danja SarinkAnna Peeters
Mar 31, 2016·Australian and New Zealand Journal of Public Health·Christopher M HarrisonHelena C Britt
Jun 17, 2016·Journal of the American Geriatrics Society·Heather E WhitsonSusan N Hastings
Jul 28, 2016·Risk Management and Healthcare Policy·Steven M McPhail
Oct 3, 2017·Health Policy·Katie PalmerJoint Action on Chronic Diseases and Promoting Healthy Ageing Across the Life Cycle (JA-CHRODIS)
Feb 17, 2016·Journal of Comorbidity·Boris AzaïsMatthias Wismar
Nov 24, 2017·The European Journal of General Practice·Candan KendirJob Metsemakers
Feb 15, 2018·Australian and New Zealand Journal of Public Health·Thanya I Pathirana, Caroline A Jackson
Jun 30, 2018·The Medical Journal of Australia·Deborah A RandallLouisa Jorm
Aug 3, 2018·Journal of Primary Health Care·Elinor MillarDiana Sarfati


Nov 20, 2019·PloS One·Glenda Blaser PetarliLuciane Bresciani Salaroli
Dec 19, 2019·International Journal of Environmental Research and Public Health·S C ThompsonFrank M Sanfilippo
Feb 6, 2021·International Journal of Environmental Research and Public Health·Lydia SeeS C Thompson
May 2, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Lara Marie Pangan LoIngrid van der Mei

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.