Complexity in the tumour microenvironment: Cancer associated fibroblast gene expression patterns identify both common and unique features of tumour-stroma crosstalk across cancer types

Seminars in Cancer Biology
Paolo GandelliniMaurizio Callari

Abstract

Cancer is a complex disease, driven by the accumulation of several somatic aberrations but fostered by a two-way interaction between tumour cells and the surrounding microenvironment. Cancer associated fibroblasts (CAFs) represent one of the major players in tumour-stroma crosstalk. Recent in vitro and in vivo studies, often conducted by employing high throughput approaches, have started unravelling the key pathways involved in their functional effects. This review focus on open challenges in the study of CAF properties and function, highlighting at the same time the existence of common mechanisms as well as peculiarities in different cancer types (breast, prostate and lung cancer). Although still limited by current experimental models, which are unable to deal with the full level of complexity of the tumour microenvironment, a better understanding of these mechanisms may enable the identification of new biomarkers and therapeutic targets, to improve current strategies for cancer diagnosis and treatment.

References

Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D A BronzertM E Lippman
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·A J KoleskeM P Lisanti
May 1, 1993·Clinical Immunology and Immunopathology·Y KatzE Lahat
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·D PennicaA J Levine
Mar 10, 2001·Experimental Cell Research·B Elenbaas, R A Weinberg
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jianyong ShouWei-Qiang Gao
Mar 20, 2002·Nature Reviews. Cancer·M J Bissell, D Radisky
Sep 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Howard Y ChangPatrick O Brown
Jul 21, 2004·Cancer Cell·Minna AllinenKornelia Polyak
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shinya IshikawaFumihiro Tanaka
Nov 19, 2004·Nature·Neil A BhowmickHarold L Moses
Jan 4, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Cui YazhouWu Licun
Apr 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Meghna WaghrayVictor J Thannickal
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Mar 18, 2006·American Journal of Respiratory and Critical Care Medicine·Chakradhar KotaruSally E Wenzel
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth
Aug 2, 2006·Cell Cycle·Akira Orimo, Robert A Weinberg
Sep 5, 2006·Cancer Metastasis Reviews·Sonia B Jakowlew
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Gong YangJinsong Liu
Nov 16, 2006·Cancer Biology & Therapy·Hikaru SugimotoRaghu Kalluri
May 26, 2007·The American Journal of Pathology·Boris HinzGiulio Gabbiani
Sep 28, 2007·Breast Cancer Research and Treatment·Christian F SingerErnst Kubista
Nov 30, 2007·The Journal of Pathology·A BergamaschiA-L Børresen-Dale
Feb 5, 2008·Cancer Research·Rosa F HwangCraig D Logsdon
Apr 29, 2008·Nature Medicine·Greg FinakMorag Park
May 10, 2008·Bioinformatics·Pan DuSimon M Lin
Dec 5, 2008·Trends in Genetics : TIG·Kornelia PolyakIan G Campbell
Jan 22, 2009·Cancer Research·Ermira PazolliSheila A Stewart
Feb 4, 2009·Breast Cancer Research : BCR·Xiao-Jun MaDennis C Sgroi
May 5, 2009·The American Journal of Pathology·Agnieszka K WitkiewiczMichael P Lisanti
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chunyu ZhangXin-Yuan Guan
Jan 12, 2010·American Journal of Respiratory Cell and Molecular Biology·Dmitri V PechkovskyDarryl A Knight

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Citations

Jan 15, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Elizabete BagordakisRicardo D Coletta
Oct 13, 2015·Seminars in Cancer Biology·Ira Skvortsova
Sep 8, 2016·Microarrays·Giuseppe MerlinoVera Cappelletti
Oct 25, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Francesco FacchinettiMarcello Tiseo
May 9, 2012·Seminars in Immunology·Beata Berent-MaozKenneth Dorshkind
Oct 12, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xuan HongQingyong Xu
Mar 10, 2018·Journal of Cellular Physiology·Marta GiussaniElda Tagliabue
Aug 8, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mauricio Rocha DouradoRicardo D Coletta
May 25, 2018·Journal of Cell Science·Francesca NardiSusan E Crawford
Sep 7, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Eugene Sverdlov
Oct 4, 2017·Theoretical Biology & Medical Modelling·Youcef Derbal
May 30, 2020·Assay and Drug Development Technologies·Manar Zraikat, Tasneem Alshelleh
Nov 7, 2019·Biochemistry. Biokhimii︠a︡·E D Sverdlov, I P Chernov
Jan 16, 2016·Clinical Science·Zied BoudhraaFrançoise Degoul
Jul 4, 2017·Molecular Oncology·Giuseppe MerlinoMaria Grazia Daidone
Jul 28, 2016·Biochemistry. Biokhimii︠a︡·E D Sverdlov
May 28, 2020·International Journal of Molecular Sciences·Bagora BayalaJean-Marc A Lobaccaro
Oct 5, 2016·Molecular and Clinical Oncology·Xavier CatteauJean-Christophe Noël
Jun 28, 2017·Cancer Research·Sadiq M I SalehMorag Park
Sep 4, 2020·Journal of Dental Research·H ZhaoZ Shang
May 1, 2021·International Journal of Molecular Sciences·Lara Malik NoureddineCoralie Poulard

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