Complexity of cancer protease biology: Cathepsin K expression and function in cancer progression

Seminars in Cancer Biology
Urška VerbovšekTamara T Lah

Abstract

Proteases, including lysosomal cathepsins, are functionally involved in many processes in cancer progression from its initiation to invasion and metastatic spread. Only recently, cathepsin K (CatK), the cysteine protease originally reported as a collagenolytic protease produced by osteoclasts, appeared to be overexpressed as well in various types of cancers. In this review, the physiological functions of CatK are presented and compared to its potential role in pathobiolology of processes associated with tumour growth, invasion and metastasis of cancer cells and their interactions with the tumour microenvironment. CatK activity is either indirectly affecting signalling pathways, or directly degrading extracellular matrix (ECM) proteins, for example in bone metastases. Recently, CatK was also found in glioma, possibly regulating cancer stem-like cell mobilisation and modulating recently found physiological CatK substrates, including chemokines and growth factors. Moreover, CatK may be useful in differential diagnosis and may have prognostic value. Finally, the application of CatK inhibitors, which are already in clinical trials for treatment of osteoporosis, has a potential to attenuate cancer aggressiveness.

References

Jan 2, 1992·International Journal of Cancer. Journal International Du Cancer·T T LahV Turk
Jul 15, 1991·Biochemical and Biophysical Research Communications·C J van Noorden, V Everts
Jul 1, 1989·Clinical & Experimental Metastasis·T T LahB F Sloane
Sep 1, 1988·Calcified Tissue International·V EvertsR Schröder
Jan 1, 1985·Calcified Tissue International·V EvertsW Beertsen
Sep 1, 1994·Human Pathology·T CastiglioniM R Emmert-Buck
May 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O H Sanchez-SweatmanG Singh
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·P SaftigK von Figura
Nov 21, 1998·The Journal of Biological Chemistry·P GarneroJ M Delaissé
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·F BühlingT Welte
Oct 27, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C HaeckelA Roessner
Jan 19, 2000·Current Pharmaceutical Design·D S Yamashita, R A Dodds
Sep 16, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L G HazenC J Van Noorden
Feb 27, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·M SöderströmE Vuorio
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·G MotyckovaD E Fisher
Dec 6, 2001·The American Journal of Pathology·W S HouD Brömme
Jul 3, 2002·Nature Reviews. Molecular Cell Biology·Carlos López-Otín, Christopher M Overall
Feb 6, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K D BrubakerE Corey
Mar 6, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·Vanita Bhavnani, Aileen Clarke
Mar 26, 2003·Journal of Cellular Physiology·Chiara ChielliniMargherita Maffei
May 10, 2003·Journal of Women's Health·Karen K Miller
Jul 3, 2003·Nature Reviews. Genetics·Xose S PuenteCarlos López-Otín
Dec 3, 2003·The Journal of Biological Chemistry·Zhenqiang LiDieter Brömme
May 27, 2004·The American Journal of Pathology·Frank BühlingTobias Welte
Jul 28, 2004·The American Journal of Pathology·Jan H N LindemanPancras C W Hogendoorn
Dec 4, 2004·Biological Chemistry·Christopher Jedeszko, Bonnie F Sloane
May 7, 2005·Advanced Drug Delivery Reviews·Yoshiyuki YasudaDieter Brömme
Sep 27, 2005·Cancer Detection and Prevention·Tadej StrojnikTamara T Lah
Feb 17, 2006·Genes & Development·Vasilena GochevaJohanna A Joyce
Mar 1, 2006·Expert Opinion on Biological Therapy·Tamara T LahCornelis J F Van Noorden
Mar 22, 2006·International Journal of Cancer. Journal International Du Cancer·Thomas FlanneryPatrick G Johnston
Jun 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chao Yang LiMitchell B Schaffler

❮ Previous
Next ❯

Citations

Oct 13, 2015·Seminars in Cancer Biology·Ira Skvortsova
Mar 24, 2016·Expert Opinion on Drug Discovery·Dieter BrömmeSerap Turan
Apr 24, 2016·Biochemical Pharmacology·Kakoli Mukherjee, Naibedya Chattopadhyay
May 24, 2016·European Journal of Medicinal Chemistry·Elżbieta PlebanekLuigi A Agrofoglio
Oct 27, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Maria SiponenTuula Salo
Dec 22, 2016·Biological Chemistry·Barbara BreznikTamara Lah Turnšek
Jan 20, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·A L OeiJ Crezee
Jan 5, 2018·International Journal of Molecular Sciences·Annie Schmid-AllianaElise Verron
Jan 13, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Vashendriya V V HiraCornelis J F van Noorden
Oct 28, 2018·Radiology and Oncology·Barbara BreznikTamara T Lah
Jun 20, 2019·Cell Cycle·Surinder M SoondAndrey A Zamyatnin
Oct 1, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Vashendriya V V HiraCornelis J F Van Noorden
Aug 20, 2019·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Mona N OliveiraTamara T Lah
Jan 7, 2020·Biological & Pharmaceutical Bulletin·Kohei HosokawaMasahiro Fujimuro
Feb 29, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Charlotte H J R JansenCornelis J F Van Noorden
Jan 13, 2019·Cancers·Pernille B ElmingMichael R Horsman
Jul 27, 2018·Journal of Molecular Histology·Barbara BreznikCornelis J F Van Noorden
Apr 25, 2020·Cells·Valeria De PasqualeLuigi Michele Pavone
May 1, 2021·International Journal of Molecular Sciences·Tamara Lah TurnšekRichard G Pestell
Jul 27, 2021·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Anamarija HabičBarbara Breznik
Jul 31, 2019·Journal of Medicinal Chemistry·Lorenzo CianniCarlos A Montanari
Jun 20, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Bernarda MajcTamara T Lah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Related Papers

The Journal of Investigative Dermatology
Maria J Quintanilla-DieckThomas M Rünger
Journal of Veterinary Internal Medicine
J M SchmitT M Fan
Journal of the European Academy of Dermatology and Venereology : JEADV
X YanM Furue
Cancer Detection and Prevention
Tadej StrojnikTamara T Lah
© 2021 Meta ULC. All rights reserved