Complexity of Generating Mouse Models to Study the Upper Motor Neurons: Let Us Shift Focus from Mice to Neurons.

International Journal of Molecular Sciences
Barış GençP Hande Özdinler

Abstract

Motor neuron circuitry is one of the most elaborate circuitries in our body, which ensures voluntary and skilled movement that requires cognitive input. Therefore, both the cortex and the spinal cord are involved. The cortex has special importance for motor neuron diseases, in which initiation and modulation of voluntary movement is affected. Amyotrophic lateral sclerosis (ALS) is defined by the progressive degeneration of both the upper and lower motor neurons, whereas hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS) are characterized mainly by the loss of upper motor neurons. In an effort to reveal the cellular and molecular basis of neuronal degeneration, numerous model systems are generated, and mouse models are no exception. However, there are many different levels of complexities that need to be considered when developing mouse models. Here, we focus our attention to the upper motor neurons, which are one of the most challenging neuron populations to study. Since mice and human differ greatly at a species level, but the cells/neurons in mice and human share many common aspects of cell biology, we offer a solution by focusing our attention to the affected neurons to reveal the complexities of disease...Continue Reading

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Citations

Oct 20, 2020·Frontiers in Cell and Developmental Biology·Stefan HauserLudger Schöls
Oct 3, 2020·Experimental Neurology·Frederique WietersMarkus Aswendt
Feb 20, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·P Hande OzdinlerGeorg Haase
Dec 17, 2020·Seminars in Cell & Developmental Biology·Aksu GunayP Hande Ozdinler
May 4, 2021·Journal of Alzheimer's Disease : JAD·Vasily VorobyovAleksey A Ustyugov
Jun 3, 2021·Brain Sciences·Roger N Lemon
Aug 28, 2021·Brain Sciences·Parvathi Menon, Steve Vucic
Aug 28, 2021·Brain Sciences·Neha MohanPeter W Baas

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Methods Mentioned

BETA
transgenic

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