Complexity of glandular architecture should be reconsidered in the classification and management of endometrial hyperplasia

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Antonio TravaglinoFulvio Zullo

Abstract

The 2014 World Health Organization (WHO) classification of endometrial hyperplasia (EH) defines premalignant EH based on only cytologic atypia, disregarding architecture complexity. We aimed to assess the impact of architecture complexity on the risk of cancer in non-atypical EH. A systematic review and meta-analysis was performed by searching electronic databases form their inception to October 2018. All studies assessing the rates of progression to cancer in non-atypical EH (simple vs complex) were included. Pooled relative risk (RR) for cancer progression was calculated; a p-value < 0.05 was considered significant. Eight studies with 1066 women were included. The risk for progression of non-atypical EH to cancer was significantly higher in complex EH than in simple EH (p < 0.0001), with an RR of 4.90. In conclusion, the complexity of glandular architecture significantly increases the risk of cancer in non-atypical EH. Complex non-atypical EH may be regarded as a low-risk premalignant lesion rather than a benign condition.

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Oct 21, 2018·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Antonio TravaglinoFulvio Zullo
Oct 23, 2018·Histopathology·Antonio TravaglinoFulvio Zullo
Dec 5, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneFulvio Zullo

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Citations

Aug 14, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio TravaglinoFulvio Zullo
Aug 25, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneMaurizio Guida
Oct 5, 2019·American Journal of Clinical Pathology·Antonio TravaglinoMassimo Mascolo
Aug 25, 2019·Pathology Oncology Research : POR·Antonio RaffoneGian Franco Zannoni
Mar 18, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneFulvio Zullo
Sep 23, 2019·Archives of Gynecology and Obstetrics·Ruggero LionettiFrancesco Corcione
Feb 23, 2020·American Journal of Clinical Pathology·Antonio TravaglinoMassimo Mascolo
Apr 17, 2020·Archives of Gynecology and Obstetrics·Antonio TravaglinoFulvio Zullo
Sep 19, 2019·Archives of Gynecology and Obstetrics·Antonio TravaglinoFulvio Zullo
Mar 28, 2019·Archives of Gynecology and Obstetrics·Antonio RaffoneFulvio Zullo
Aug 23, 2019·American Journal of Clinical Pathology·Antonio TravaglinoFulvio Zullo
Apr 8, 2020·Archives of Gynecology and Obstetrics·Antonio TravaglinoFulvio Zullo
Jun 27, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio RaffoneFulvio Zullo
Jun 17, 2019·Pathology Oncology Research : POR·Antonio RaffoneFulvio Zullo
Jun 20, 2020·Pathology Oncology Research : POR·Antonio TravaglinoMassimo Mascolo
Dec 20, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Antonio TravaglinoFulvio Zullo
Jan 15, 2020·Gynecologic Oncology·Antonio RaffoneFulvio Zullo
Feb 24, 2020·Pathology, Research and Practice·Antonio TravaglinoMassimo Mascolo
Feb 23, 2021·Pathology, Research and Practice·Antonio TravaglinoMassimo Mascolo
Apr 1, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio TravaglinoLuigi Insabato
Sep 22, 2020·Pathology, Research and Practice·Raduan Ahmed FrancaMassimo Mascolo

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