Complexity of the primary genetic response to mitogenic activation of human T cells.

Molecular and Cellular Biology
P F ZipfelU Siebenlist

Abstract

We describe the isolation and characterization of more than 60 novel cDNA clones that constitute part of the immediate genetic response to resting human peripheral blood T cells after mitogen activation. This primary response was highly complex, both in the absolute number of inducible genes and in the diversity of regulation. Although most of the genes expressed in activated T cells were shared with the activation response of normal human fibroblasts, a significant number were more restricted in tissue specificity and thus likely encode or effect the differentiated functions of activated T cells. The activatable genes could be further differentiated on the basis of kinetics of induction, response to cycloheximide, and sensitivity to the immunosuppressive drug cyclosporin A. It is of note that cyclosporin A inhibited the expression of more than 10 inducible genes, which suggests that this drug has a broad genetic mechanism of action.

References

Mar 1, 1987·The Journal of Experimental Medicine·J JongstraA M Krensky
May 1, 1988·Molecular and Cellular Biology·J M AlmendralR Bravo
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B S KwonS M Weissman
Jan 1, 1987·Advances in Immunology·A Weiss, J B Imboden
Jan 1, 1986·Annual Review of Immunology·W C Greene, W J Leonard
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C ReedR G Hoover
Jan 1, 1986·Annual Review of Genetics·M D Cole
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K RyderD Nathans
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L F Lau, D Nathans
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C G LobeR C Bleackley
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J Y ChanJ C Gasson
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M A Alonso, S M Weissman
Jan 1, 1986·Annual Review of Immunology·K Kelly, U Siebenlist
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Jun 22, 1984·Science·D A Cantrell, K A Smith

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Citations

Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·T K TeagueP Marrack
Sep 2, 1998·Molecular Plant-microbe Interactions : MPMI·D M HorvathN H Chua
Mar 1, 1993·Journal of Cellular Biochemistry·D A Tipton, M K Dabbous
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J LeeR Taub
May 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D E CressmanR Taub
Nov 1, 1989·Cell and Tissue Kinetics·G P Studzinski
Aug 1, 1992·European Journal of Immunology·L Stitz
Jul 1, 1994·Cancer Immunology, Immunotherapy : CII·E WeidmannT L Whiteside
Jan 1, 1993·European Journal of Immunology·K Kawakami, D C Parker
Apr 16, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A Lacy-HulbertR Hesketh
Dec 13, 1997·Biochimica Et Biophysica Acta·P F ZipfelC Skerka
Jan 1, 1990·Molecular Aspects of Medicine·T N Dear, R F Kefford
Jun 1, 1991·Current Opinion in Immunology·C H June
Aug 8, 2021·International Journal of Molecular Sciences·Maroun Bou ZerdanHazem I Assi

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