Compliance with a three-day course of artesunate-mefloquine combination and baseline anti-malarial treatment in an area of Thailand with highly multidrug resistant falciparum malaria.

Malaria Journal
Kanungnit CongpuongKesara Na-Bangchang

Abstract

Artemisinin-based combination therapy (ACT) is presently recommended by the World Health Organization as first-line treatment for uncomplicated Plasmodium falciparum malaria in several countries, as a mean of prolonging the effectiveness of first-line malaria treatment regimens. A three-day course of artesunate-mefloquine (4 mg/kg body weight once daily for three consecutive days, plus 15 and 10 mg/kg body weight mefloquine on the first and second days) has been adopted by Malaria Control Programme of Thailand as first-line treatment for uncomplicated falciparum malaria all over the country since 2008. The gametocytocydal anti-malarial drug primaquine is administered at the dose of 30 mg (0.6 mg/kg) on the last day. The aim of the present study was to assess patient compliance of this combination regimen when applied to field condition. A total of 240 patients (196 males and 44 females) who were attending the malaria clinics in Mae-Sot, Tak Province and presenting with symptomatic acute uncomplicated falciparum malaria, with no reappearance of Plasmodium vivax parasitaemia during follow-up were included into the study. The first dose of the treatment was given to the patients under direct supervision. All patients were given th...Continue Reading

References

Oct 1, 1990·Clinical Pharmacokinetics·J Karbwang, N J White
Mar 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·K N BangchangJ Karbwang
Aug 6, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·K CongpuongJ Karbwang
Jan 30, 1999·Antimicrobial Agents and Chemotherapy·R PriceN J White
Feb 24, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·R McGreadyF Nosten
Mar 5, 2002·British Journal of Clinical Pharmacology·J A SImpsonN J White
Jun 19, 2003·The American Journal of Tropical Medicine and Hygiene·Yupin SuputtamongkolVisanu Thamlikitkul
Sep 14, 2004·Tropical Medicine & International Health : TM & IH·Charlotte MuhekiKaren I Barnes
Aug 28, 2009·Fundamental & Clinical Pharmacology·Kesara Na-Bangchang, Juntra Karbwang

❮ Previous
Next ❯

Citations

Feb 12, 2011·International Journal of Pharmaceutics·C SlabbertA F Kotzé
Sep 28, 2010·Experimental Parasitology·Hong WangWu-Chun Cao
Sep 5, 2013·The American Journal of Tropical Medicine and Hygiene·Nongluk SeethornKesara Na-Bangchang
Nov 12, 2017·Parasitology Research·Papichaya PhompraditKesara Na-Bangchang
May 10, 2013·Expert Review of Clinical Pharmacology·Kesara Na-Bangchang, Juntra Karbwang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.