PMID: 9529466Apr 8, 1998Paper

Compliance with penicillin prophylaxis in patients with sickle cell disease

Archives of Pediatrics & Adolescent Medicine
S J TeachM Grossi

Abstract

To assess factors related to compliance with penicillin prophylaxis among patients with sickle cell disease. Prospective case series. Urban pediatric medical center where universal penicillin prophylaxis is recommended for all patients with any sickle cell hemoglobinopathy independent of age. Eligible patients with sickle cell hemoglobinopathies were enrolled in either the emergency department or the sickle cell clinic. Compliance was assessed by structured interview and by urine assay with an established method (Micrococcus luteus with disk diffusion) that detects excreted penicillin up to 15 hours after each dose administration. Of the 159 patients actively followed up at the sickle cell center, 123 (77.3%) eligible patients were enrolled. Reported compliance by structured interview (> or = 1 dose of penicillin V potassium within 15 hours of enrollment) was 83 of 123 patients (67.5%; 95% confidence interval, 59.2%-75.8%), whereas measured compliance as determined by urine assay was 53 of 123 patients (43.1%; 95% confidence interval, 31.3%-51.7%). Measured compliance was significantly greater in patients younger than 5 years than in those older than 5 years (25/41 [61%] vs 28/82 [34%], respectively; P = .004), and was signific...Continue Reading

Citations

Mar 21, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amanda J DriscollDavid R Murdoch
Jun 18, 2002·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Ellen Wright Clayton
Sep 11, 2007·Infectious Disease Clinics of North America·Victoria E PriceE Lee Ford-Jones
Jun 29, 2005·British Journal of Haematology·R Neil DaltonDavid C Rees
Mar 2, 2011·Pediatric Blood & Cancer·Julie A WolfsonMichele D Kipke
Jan 13, 2011·Pediatric Blood & Cancer·Julie A WolfsonMichele D Kipke
Sep 20, 2015·Journal of Pediatric Psychology·Kristin LoiselleAhna L H Pai
Jun 6, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Catherine BoothStephen K Obaro
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Dec 3, 2003·Psychological Reports·Timothy K DaughertyMelissa McClelland
Jan 10, 2012·The Pediatric Infectious Disease Journal·Angela M EllisonKim Smith-Whitley
Jan 5, 2012·Journal of Pediatric Hematology/oncology·Shalu NarangGeoffrey A Weinberg
Nov 7, 2017·Archives of Disease in Childhood·Allison StreetlyElizabeth Dormandy
Oct 30, 2020·Journal of Managed Care & Specialty Pharmacy·Hyeun Ah Kang, Jamie C Barner
Mar 17, 2021·The Cochrane Database of Systematic Reviews·Angela E Rankine-Mullings, Shirley Owusu-Ofori

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