Compliance with pregnancy prevention plan recommendations in 8672 French women of childbearing potential exposed to acitretin

Pharmacoepidemiology and Drug Safety
Fanny RaguideauFrançois Alla

Abstract

Acitretin is an oral synthetic aromatic analogue of retinoic acid available in most European countries since 1988. It is mainly used to treat severe psoriasis. Like all systemic retinoids, acitretin is teratogenic. Strict pregnancy prevention is required in women of childbearing potential who use acitretin. This study assessed compliance with Pregnancy Prevention Plan (PPP) recommendations, specifically looking at compliance with pregnancy testing (PT) and pregnancy occurrence. A cohort of 8672 women aged 15-49 years initiating acitretin treatment from 1 January 2007 through 31 December 2013 was identified using French SNIIRAM (administrative claims data) and PMSI (hospitalisations data) databases. Pregnancy tests (PTs) were identified from reimbursed serum βHCG and urine laboratory PTs. To satisfy PT criteria, patients who started treatment had to undergo a PT within 3 days before acitretin was dispensed. Pregnancies were identified by a pregnancy-related hospital stay or an outpatient medical abortion. A PT was performed in only 12% of women starting treatment and was rarely performed during treatment or during the 24 months following discontinuation of treatment. Compliance with PPP recommendations although poor appeared to ...Continue Reading

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Citations

Apr 27, 2016·American Journal of Clinical Dermatology·Inês Raposo, Tiago Torres
Dec 6, 2016·Statistics in Medicine·Frank Rockhold
Sep 13, 2020·Birth Defects Research·Wejdan A ShroukhSarah C Willis
May 26, 2017·The Australasian Journal of Dermatology·Marius RademakerJohn Sullivan
Jul 2, 2020·Clinical, Cosmetic and Investigational Dermatology·Zainab A RashidMuaed Jamal Alomar
Jun 3, 2021·Journal of Clinical Medicine·Magdalena Krajewska-WłodarczykAgnieszka Owczarczyk-Saczonek
Jul 2, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Alnada Abdalla Mohamed IbrahimMaram Alfawaz
Oct 7, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Pierre-Olivier BlotièreGéric Maura

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