PMID: 9545027Apr 17, 1998Paper

Compliant realignment of binding sites in muscle: transient behavior and mechanical tuning

Biophysical Journal
Thomas L DanielP Bryant Chase

Abstract

The presence of compliance in the lattice of filaments in muscle raises a number of concerns about how one accounts for force generation in the context of the cross-bridge cycle--binding site motions and coupling between cross-bridges confound more traditional analyses. To explore these issues, we developed a spatially explicit, mechanochemical model of skeletal muscle contraction. With a simple three-state model of the cross-bridge cycle, we used a Monte Carlo simulation to compute the instantaneous balance of forces throughout the filament lattice, accounting for both thin and thick filament distortions in response to cross-bridge forces. This approach is compared to more traditional mass action kinetic models (in the form of coupled partial differential equations) that assume filament inextensibility. We also monitored instantaneous force generation, ATP utilization, and the dynamics of the cross-bridge cycle in simulations of step changes in length and variations in shortening velocity. Three critical results emerge from our analyses: 1) there is a significant realignment of actin-binding sites in response to cross-bridge forces, 2) this realignment recruits additional cross-bridge binding, and 3) we predict mechanical beha...Continue Reading

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Citations

Mar 17, 2011·Pflügers Archiv : European journal of physiology·Kenneth S Campbell
May 29, 2008·Annals of Biomedical Engineering·D A Smith, S M Mijailovich
Dec 23, 2004·Journal of Molecular Histology·Edmund J CrampinPeter J Hunter
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Dec 15, 2010·PLoS Computational Biology·C David WilliamsThomas L Daniel
Nov 21, 2012·PLoS Computational Biology·C David WilliamsThomas L Daniel
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Mar 27, 2012·Cellular and Molecular Bioengineering·Takumi WashioToshiaki Hisada
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Jun 9, 2016·PLoS Computational Biology·Gudrun Schappacher-TilpWalter Herzog

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