Complicating Infections Associated with Common Endemic Human Respiratory Coronaviruses.

Health Security
Nevio Cimolai


Coronaviruses OC43, 229E, NL63, and HKU1 are endemic human respiratory coronaviruses that typically cause mild to moderate upper respiratory infections, similar to the common cold. They also may cause simple and complicated lower respiratory infections, otitis media, asthma exacerbations, gastroenteritis, and a few systemic complications. These viruses are usually seasonal (with winter dominance) and affect nearly all age groups. The seasonal and annual variation in virus prevalence has implications for understanding the concept of acquired immunity and its persistence or diminution. Coronaviruses generally have outbreak potential in susceptible populations of any age, particularly in patients with comorbidities, who tend to have increased clinical disease. These 4 coronaviruses are often found in the context of what appears to be coinfection with other pathogens, but especially other viruses. If coronaviruses are not specifically tested for, the sole detection of a viral copathogen would suggest the pathogen is the causative agent, when a coronavirus may be culpable, or both. The detection of these viruses in circumstances where respiratory viruses are generally sought in clinical samples is, therefore, justified. These pathog...Continue Reading


Mar 1, 1975·American Journal of Epidemiology·H S Kaye, W R Dowdle
May 1, 1992·Annals of Neurology·R S MurrayG F Cabirac
Oct 1, 1990·Epidemiology and Infection·K A CallowD A Tyrrell
Nov 1, 1974·The Journal of Infectious Diseases·K McIntoshM A Mufson
Mar 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·R A BucknallR M Chanock
Jan 1, 1980·Journal of Medical Virology·H Riski, T Hovi
Jul 1, 1983·Archives of Disease in Childhood·D IsaacsM R MacNaughton
Feb 1, 1995·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J GiudicelliG Bellon
May 13, 1995·BMJ : British Medical Journal·S L JohnstonD A Tyrrell
Jan 1, 1995·Journal of the American Geriatrics Society·A R FalseyJ J Treanor
Oct 1, 1993·Epidemiology and Infection·M J WiselkaK G Nicholson
Jun 1, 1997·Journal of the American Geriatrics Society·A R FalseyJ E Kolassa
Dec 17, 1998·Archives of Internal Medicine·R L AtmarS B Greenberg
Aug 12, 1999·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·F FreymuthB Guillois
Sep 3, 1999·American Journal of Respiratory and Critical Care Medicine·E E WalshP A Hennessey
Jul 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H M El-SahlyS B Greenberg
May 10, 2002·The Journal of Infectious Diseases·Ann R FalseyFrederick G Hayden
Apr 10, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Astrid VabretFrançois Freymuth
Sep 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frédéric PenePierre Lebon
May 1, 2004·Medical Microbiology and Immunology·H F RabenauH W Doerr
Jan 14, 2005·Journal of Medical Virology·Takashi EbiharaHideaki Kikuta
Jan 14, 2005·Journal of Medical Virology·Katherine E ArdenIan M Mackay
Jan 19, 2005·The Journal of Infectious Diseases·Nathalie BastienYan Li
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Deepali KumarAtul Humar
Aug 17, 2005·Emerging Infectious Diseases·Astrid VabretFrançois Freymuth
Aug 18, 2005·PLoS Medicine·Lia van der HoekKlaus Uberla
Sep 8, 2005·Journal of Clinical Microbiology·Nathalie BastienYan Li
Nov 1, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Theo P SlootsIan M Mackay
Nov 12, 2005·The Pediatric Infectious Disease Journal·Laurent KaiserUrs Frey
Feb 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Astrid VabretFrançois Freymuth
May 18, 2006·Emerging Infectious Diseases·Frank EsperJeffrey S Kahn
Jun 8, 2006·Journal of Clinical Microbiology·Susanna K P LauKwok-yung Yuen

❮ Previous
Next ❯


Mar 24, 2021·SN Comprehensive Clinical Medicine·Nevio Cimolai
Mar 30, 2021·Medical Hypotheses·Nevio Cimolai
Nov 17, 2020·SN Comprehensive Clinical Medicine·Nevio Cimolai
May 4, 2021·SN Comprehensive Clinical Medicine·Nevio Cimolai
Jun 12, 2021·American Journal of Infection Control·Elif Kıymetİlker Devrim
Apr 7, 2021·The Journal of Infectious Diseases·Ricardo da Silva AntunesAlessandro Sette
Aug 28, 2021·Biology·Irina Kiseleva, Andrey Ksenafontov

❮ Previous
Next ❯

Methods Mentioned

bronchoalveolar lavage

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the Pediatric Infectious Diseases Society
Chikara OgimiJanet A Englund
Current Opinion in Pediatrics
Jeffrey S Kahn
Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada
Philippe Lagacé-WiensPaul Van Caeseele
© 2021 Meta ULC. All rights reserved