Abstract
Systemic complications are common in status epilepticus. We have no tools to evaluate total burden of complications and its effect on the outcome of status epilepticus. For Complication Burden Index (CBI) a patient is assessed for 13 complication categories: respiratory, cardiovascular, nervous, renal, hepatic, coagulation, gastrointestinal and musculoskeletal systems, electrolyte/acid-base balance, infection, hypo-/hyperglycemia, skin/allergic reactions, and mental condition. Maximum CBI is 13. CBI was internally validated in a retrospective cohort of 70 consecutive adult patients with generalized convulsive status epilepticus (GCSE) treated in a tertiary hospital over a period of 2 years. Functional outcome at discharge was defined Poor for Glascow Outcome Scale (GOS) 1-3 or worse-than-baseline condition and Good for GOS >3 or return to baseline condition. Relative risks (RRs) and receiver-operating characteristic (ROC) -curves were calculated to obtain optimal cutoff. Functional outcome was poor in 40% and worse-than-baseline in 59%. In-hospital mortality was 7%. Average CBI was 3.8 (range 0-10, median 3). Cutoff value predicting poor functional outcome was a CBI >3 (GOS 1-3 RR 1.84, P = .045, 95% confidence interval [CI 1.0...Continue Reading
References
Dec 1, 1991·Chest·W A KnausA Damiano
Nov 1, 1980·The American Journal of Medicine·M J Aminoff, R P Simon
Oct 1, 1995·Critical Care Medicine·J C MarshallW J Sibbald
Dec 22, 1993·JAMA : the Journal of the American Medical Association·J R Le GallF Saulnier
Jan 1, 1993·Epilepsy Research·J G BoggsR J DeLorenzo
Jul 1, 1996·Intensive Care Medicine·J L VincentL G Thijs
Aug 29, 2007·Neurology·Mohamad Koubeissi, Amer Alshekhlee
Oct 30, 2007·Intensive Care Medicine·Stéphane LegrielFrançois Hilpert
Mar 11, 2008·Epilepsia·Felix RosenowSusanne Knake
Sep 5, 2008·Journal of Neurology·Andrea O RossettiEdward B Bromfield
Nov 21, 2008·Seizure : the Journal of the British Epilepsy Association·D V SokicA J Ristic
Jun 27, 2012·Critical Care Medicine·Robert G KowalskiRomergryko G Geocadin
Jul 21, 2012·Epilepsia·Raoul SutterStephan Rüegg
Nov 20, 2012·Epilepsia·Sara HockerAlejandro A Rabinstein
Jan 16, 2013·JAMA Neurology·Sara E HockerAlejandro A Rabinstein
May 28, 2014·Seizure : the Journal of the British Epilepsy Association·Johan ZelanoEva Kumlien
Nov 22, 2014·Neurocritical Care·M LeitingerE Trinka
May 1, 2015·Critical Care : the Official Journal of the Critical Care Forum·Alexandre LaiPierre-Edouard Bollaert
May 15, 2015·Epilepsy & Behavior : E&B·Sara Hocker
Sep 5, 2015·Epilepsia·Eugen TrinkaDaniel H Lowenstein
Jan 5, 2016·Journal of Neurology·Dominik MadžarHagen B Huttner
Feb 27, 2016·Critical Care : the Official Journal of the Critical Care Forum·Qiong GaoWen Jiang
Jul 15, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M González-CuevasJ Salas-Puig
Jan 16, 2017·Clinical Neurology and Neurosurgery·Marco BelluzzoFabrizio Monti
Citations
Jul 3, 2020·Acta Neurologica Scandinavica·Edoardo CaronnaEstevo Santamarina
Nov 11, 2019·Seizure : the Journal of the British Epilepsy Association·Donald P CraigRhys H Thomas
Oct 30, 2021·Clinical EEG and Neuroscience·Nese DericiogluMehmet Akif Topcuoglu